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<p>Malignant testicular germ cell tumors exhibit significant histologic diversity, particularly across pediatric age groups. Prepubertal patients more commonly develop yolk sac tumors, whereas postpubertal adolescents are more likely to present with mixed germ cell tumors arising from germ cell neoplasia in situ. Although clinical presentations may vary, histologic evaluation and immunohistochemistry remain the cornerstone of diagnosis. Additionally, molecular findings—especially the presence of isochromosome 12p—play a crucial role in prognosis. This review underscores the developmental origins and heterogeneity of malignant testicular germ cell tumors in pediatric populations and provides some contrast with their development in adults.</p>

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Pediatric malignant testicular germ cell tumors: a developmental and comparative perspective

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月27日

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  • Sonja Chen,
  • Andres Matoso

摘要

Malignant testicular germ cell tumors exhibit significant histologic diversity, particularly across pediatric age groups. Prepubertal patients more commonly develop yolk sac tumors, whereas postpubertal adolescents are more likely to present with mixed germ cell tumors arising from germ cell neoplasia in situ. Although clinical presentations may vary, histologic evaluation and immunohistochemistry remain the cornerstone of diagnosis. Additionally, molecular findings—especially the presence of isochromosome 12p—play a crucial role in prognosis. This review underscores the developmental origins and heterogeneity of malignant testicular germ cell tumors in pediatric populations and provides some contrast with their development in adults.