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Background <p>The Dietary Index for Gut Microbiota (DI-GM) is a dietary quality indicator of gut health, weekend warrior (WW) has grown increasingly prevalent in today’s fast-paced lifestyle. The association of DI-GM and WW with mortality in hypertensive populations is currently unclear. This study aimed to explore the independent and joint associations of DI-GM and WW physical activity pattern with mortality among hypertensive patients.</p> Methods <p>Utilizing data from 9082 hypertensive patients in the NHANES 2007–2018. The WW physical activity pattern was assessed using the self-reported Global Physical Activity Questionnaire, and DI-GM was estimated based on 24-hour dietary recalls. Kaplan–Meier (KM) curves and the Cox proportional hazard model were used to evaluate the associations between independent and joint prognostic effects of DI-GM and WW with mortality among hypertensive patients.</p> Results <p>During a median follow-up of 6.8 years, 919 deaths were recorded. Analysis showed that DI-GM was associated with all-cause mortality in hypertensive patients (HR = 0.94, 95% CI [0.90, 0.99]). The all-cause (HR = 0.59, 95%CI 0.47 to 0.74) and cardiovascular disease (CVD) mortality (HR = 0.51, 95%CI 0.33 to 0.79) were significantly lower for weekend warriors compared with inactive individuals. The combined analysis demonstrated that, compared to individuals with low DI-GM and inactivity, those with high DI-GM and WW had a 55% lower risk of all-cause mortality, while those with low DI-GM and WW exhibited a 47% reduced risk of CVD mortality.</p> Conclusions <p>DI-GM demonstrated a significant inverse association with all-cause mortality risk among hypertensive patients. WW had similar benefits for all-cause mortality as regularly active. Our study revealed that the combination of high DI-GM diets with WW was robustly associated with reduced all-cause mortality risk in hypertensive patients.</p>

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Joint association of dietary index for gut microbiota and weekend warrior physical activity pattern with mortality among hypertensive patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月27日

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  • Jufeng Chen,
  • Yuxi Chen,
  • Sunanjie Zhao,
  • Peiya Tao,
  • Guohu Han,
  • Zhuo Wang

摘要

Background

The Dietary Index for Gut Microbiota (DI-GM) is a dietary quality indicator of gut health, weekend warrior (WW) has grown increasingly prevalent in today’s fast-paced lifestyle. The association of DI-GM and WW with mortality in hypertensive populations is currently unclear. This study aimed to explore the independent and joint associations of DI-GM and WW physical activity pattern with mortality among hypertensive patients.

Methods

Utilizing data from 9082 hypertensive patients in the NHANES 2007–2018. The WW physical activity pattern was assessed using the self-reported Global Physical Activity Questionnaire, and DI-GM was estimated based on 24-hour dietary recalls. Kaplan–Meier (KM) curves and the Cox proportional hazard model were used to evaluate the associations between independent and joint prognostic effects of DI-GM and WW with mortality among hypertensive patients.

Results

During a median follow-up of 6.8 years, 919 deaths were recorded. Analysis showed that DI-GM was associated with all-cause mortality in hypertensive patients (HR = 0.94, 95% CI [0.90, 0.99]). The all-cause (HR = 0.59, 95%CI 0.47 to 0.74) and cardiovascular disease (CVD) mortality (HR = 0.51, 95%CI 0.33 to 0.79) were significantly lower for weekend warriors compared with inactive individuals. The combined analysis demonstrated that, compared to individuals with low DI-GM and inactivity, those with high DI-GM and WW had a 55% lower risk of all-cause mortality, while those with low DI-GM and WW exhibited a 47% reduced risk of CVD mortality.

Conclusions

DI-GM demonstrated a significant inverse association with all-cause mortality risk among hypertensive patients. WW had similar benefits for all-cause mortality as regularly active. Our study revealed that the combination of high DI-GM diets with WW was robustly associated with reduced all-cause mortality risk in hypertensive patients.