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Objectives <p>To determine the detection rate, molecular characteristics, and clinical features of enterovirus and parechovirus infections in young infants with sepsis-like illness.</p> Methods <p>A prospective study conducted from September 2023 to February 2025 at four Thai tertiary hospitals enrolled infants aged 0–3 months with sepsis-like symptoms who underwent routine laboratory tests and real-time reverse transcription polymerase chain reaction for enterovirus, human rhinovirus, and parechovirus.</p> Results <p>Of 56 infants with sepsis-like illness, 15 tested positive (26.8%; 95%CI 17.0–39.6%) for enterovirus, human rhinovirus, or parechovirus. Detected viruses included echovirus 3 and 9 (<i>n</i> = 3), human rhinovirus types A, B, and C (<i>n</i> = 8), coxsackievirus A6 and B3 (<i>n</i> = 2), and parechovirus type 3 (<i>n</i> = 2). Virus-positive infants had a higher median age than virus-negative infants (39 vs. 15 days, <i>p</i> = 0.004), and neonates ≤ 1 month of age were usually virus-negative (<i>p</i> = 0.03). Virus-positive infants older than one month were more likely to have a temperature ≥ 37.5&#xa0;°C (<i>p</i> = 0.03). Cough was more common in virus-positive infants, while abdominal distension was more frequent in virus-negative infants (<i>p</i> = 0.04).</p> Conclusion <p>Enteroviruses were commonly detected in Thai infants with sepsis-like illness, with most positives attributable to enterovirus/rhinovirus group viruses, whereas parechovirus was infrequent and limited to HPeV3. Genotyping indicated established circulating lineages.</p>

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Detection rate, clinical characteristics, and molecular characterization of enterovirus and parechovirus infections in Thai infants during the first three months of life

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月18日

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  • Nanthida Phattraprayoon,
  • Py Paramagul,
  • Orawon Chirachanchai,
  • Thanatda Siriporn,
  • Waritsara Srisomboon,
  • Jiratchaya Puenpa,
  • Yong Poovorawan,
  • Nasamon Wanlapakorn

摘要

Objectives

To determine the detection rate, molecular characteristics, and clinical features of enterovirus and parechovirus infections in young infants with sepsis-like illness.

Methods

A prospective study conducted from September 2023 to February 2025 at four Thai tertiary hospitals enrolled infants aged 0–3 months with sepsis-like symptoms who underwent routine laboratory tests and real-time reverse transcription polymerase chain reaction for enterovirus, human rhinovirus, and parechovirus.

Results

Of 56 infants with sepsis-like illness, 15 tested positive (26.8%; 95%CI 17.0–39.6%) for enterovirus, human rhinovirus, or parechovirus. Detected viruses included echovirus 3 and 9 (n = 3), human rhinovirus types A, B, and C (n = 8), coxsackievirus A6 and B3 (n = 2), and parechovirus type 3 (n = 2). Virus-positive infants had a higher median age than virus-negative infants (39 vs. 15 days, p = 0.004), and neonates ≤ 1 month of age were usually virus-negative (p = 0.03). Virus-positive infants older than one month were more likely to have a temperature ≥ 37.5 °C (p = 0.03). Cough was more common in virus-positive infants, while abdominal distension was more frequent in virus-negative infants (p = 0.04).

Conclusion

Enteroviruses were commonly detected in Thai infants with sepsis-like illness, with most positives attributable to enterovirus/rhinovirus group viruses, whereas parechovirus was infrequent and limited to HPeV3. Genotyping indicated established circulating lineages.