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Background <p>Viral meningitis is a frequent cause of central nervous system (CNS) inflammation, typically presenting with headache, fever, photophobia, and neck stiffness. While enteroviruses and herpes simplex virus are the most common etiologies, Human Herpesvirus 7 (HHV-7), a rarely recognized cause, is increasingly implicated in aseptic meningitis, particularly in immunocompetent adults. HHV-7 is a T-lymphotropic virus that primarily affects CD4 + T lymphocytes, and it is globally prevalent, with over 95% of adults seropositive for the virus. Though traditionally associated with mild childhood diseases like exanthems and febrile seizures, HHV-7 has been linked to neurological complications, including meningitis, encephalitis, and myelitis.</p> Case summary <p>A 37-year-old Italian female with a 10-year history of vegetarianism and a 2-year history of pap smear-diagnosed Human Papillomavirus (HPV)-associated low-grade squamous intraepithelial dysplasia was admitted for a 3-day history of progressive worsening lower back pain radiating to bilateral posterior lower limbs and soles paresthesia. Physical examination shows bilateral positive Lasegue sign, bilateral pain upon palpation of 4/4 Valleix’s points, and absence of ankle reflexes, otherwise intact. Initial blood laboratory investigations reveal mild leukocytosis (10.92 G/L) with normal C-reactive protein (CRP), folate, and cobalamin. Cerebrospinal fluid (CSF) analysis shows 441 white blood cells/mm³, elevated protein (1.073&#xa0;g/L), and positive Pandy reaction. HHV-7 was detected via CSF polymerase chain reaction (PCR); other bacterial and viral pathogens were negative. Patient demonstrates remarkable recovery after 5 days, along with pain control.</p> Conclusion <p>We report a rare case of viral meningitis induced by HHV-7 in a 37-year-old immunocompetent female, whose initial symptoms were unusual, presenting primarily with lower limb pain and numbness. Laboratory tests revealed HHV-7 deoxyribonucleic acid (DNA) in the CSF, confirming the diagnosis of aseptic meningitis. This case emphasizes the importance of considering HHV-7 in the differential diagnosis of viral meningitis, even without classic systemic signs. Despite the absence of specific antiviral therapy for HHV-7, supportive care remains effective. This case adds to the growing evidence on HHV-7 as an under-recognized cause of aseptic meningitis, particularly in immunocompetent individuals.</p>

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Human herpesvirus 7 induced aseptic meningitis in an immunocompetent adult presenting with unusual neurological symptoms: a case report

  • 期刊论文

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  • 发表日期：

    2025年11月26日

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  • Le Cam Anh Nguyen,
  • Pham Mai Anh Nguyen,
  • Thi Hong Nhi Nguyen

摘要

Background

Viral meningitis is a frequent cause of central nervous system (CNS) inflammation, typically presenting with headache, fever, photophobia, and neck stiffness. While enteroviruses and herpes simplex virus are the most common etiologies, Human Herpesvirus 7 (HHV-7), a rarely recognized cause, is increasingly implicated in aseptic meningitis, particularly in immunocompetent adults. HHV-7 is a T-lymphotropic virus that primarily affects CD4 + T lymphocytes, and it is globally prevalent, with over 95% of adults seropositive for the virus. Though traditionally associated with mild childhood diseases like exanthems and febrile seizures, HHV-7 has been linked to neurological complications, including meningitis, encephalitis, and myelitis.

Case summary

A 37-year-old Italian female with a 10-year history of vegetarianism and a 2-year history of pap smear-diagnosed Human Papillomavirus (HPV)-associated low-grade squamous intraepithelial dysplasia was admitted for a 3-day history of progressive worsening lower back pain radiating to bilateral posterior lower limbs and soles paresthesia. Physical examination shows bilateral positive Lasegue sign, bilateral pain upon palpation of 4/4 Valleix’s points, and absence of ankle reflexes, otherwise intact. Initial blood laboratory investigations reveal mild leukocytosis (10.92 G/L) with normal C-reactive protein (CRP), folate, and cobalamin. Cerebrospinal fluid (CSF) analysis shows 441 white blood cells/mm³, elevated protein (1.073 g/L), and positive Pandy reaction. HHV-7 was detected via CSF polymerase chain reaction (PCR); other bacterial and viral pathogens were negative. Patient demonstrates remarkable recovery after 5 days, along with pain control.

Conclusion

We report a rare case of viral meningitis induced by HHV-7 in a 37-year-old immunocompetent female, whose initial symptoms were unusual, presenting primarily with lower limb pain and numbness. Laboratory tests revealed HHV-7 deoxyribonucleic acid (DNA) in the CSF, confirming the diagnosis of aseptic meningitis. This case emphasizes the importance of considering HHV-7 in the differential diagnosis of viral meningitis, even without classic systemic signs. Despite the absence of specific antiviral therapy for HHV-7, supportive care remains effective. This case adds to the growing evidence on HHV-7 as an under-recognized cause of aseptic meningitis, particularly in immunocompetent individuals.