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Background <p>The Oral Polio Vaccine (OPV) is genetically unstable and may mutate to form vaccinederived polioviruses (VDPVs). At present, the finding of VDPV mainly come from AFP surveillance and environmental sewage surveillance.</p> Methods <p>In 2023, a vaccine-derived poliovirus (VDPV) strain type 3 isolated from a patient with hand, foot, and mouth disease (HFMD) in Guangdong Province, China, was sequenced and analyzed.</p> Result <p>The strain had reversion mutations at the known attenuation site 5’ non-coding region and recombined with Sabin1, Phylogenetic analysis of the <i>VP1</i> coding region showed that the Guangdong type 3 VDPV evolved independently of other type 3 VDPVs found globally.</p> Conclusion <p>It is meaningful to increase the sensitivity of surveillance of other enteroviral diseases for polioviruses.</p>

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Genetic characterization of type 3 vaccine-derived poliovirus from a patient with hand, foot, and mouth disease in China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月28日

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  • Wei Zhang,
  • Dongmei Yan,
  • Hanri Zeng,
  • Lei Zhou,
  • Huanying Zheng,
  • Shuangli Zhu,
  • Yong Zhang,
  • Baisheng Li

摘要

Background

The Oral Polio Vaccine (OPV) is genetically unstable and may mutate to form vaccinederived polioviruses (VDPVs). At present, the finding of VDPV mainly come from AFP surveillance and environmental sewage surveillance.

Methods

In 2023, a vaccine-derived poliovirus (VDPV) strain type 3 isolated from a patient with hand, foot, and mouth disease (HFMD) in Guangdong Province, China, was sequenced and analyzed.

Result

The strain had reversion mutations at the known attenuation site 5’ non-coding region and recombined with Sabin1, Phylogenetic analysis of the VP1 coding region showed that the Guangdong type 3 VDPV evolved independently of other type 3 VDPVs found globally.

Conclusion

It is meaningful to increase the sensitivity of surveillance of other enteroviral diseases for polioviruses.