Background <p>Skilled delivery services are critical for reducing maternal and neonatal mortality, yet male involvement during labor and delivery remains inadequate in many low- and middle-income countries. Male involvement improves maternal healthcare utilization and outcomes by enhancing timely decision-making, increasing support for skilled service use, and reducing delays in seeking and receiving appropriate care. This study examined the determinants of male partner presence during labor in Winneba Municipality, Ghana.</p> Methods <p>A descriptive cross-sectional study design was employed involving 360 men. Data were collected using structured questionnaires and analyzed using SPSS version 26, employing descriptive statistics, chi-square tests, and binomial logistic regression.</p> Results <p>The majority of participants were aged 43 years and above (41.6%), married (73.3%), and self-employed (46.7%). Only 21% of men were present during childbirth. Lack of education (67.0%) and economic constraints (53.6%) were identified as the biggest barriers to male involvement. Antenatal care attendance (80.7%) was the most positively affected aspect of maternal healthcare by male involvement. Time constraints (23.8%) and gender-role perceptions (21.8%) were the primary reasons for non-accompaniment. Income above GHS 5,000 significantly predicted male involvement during delivery (OR = 4.428, 95% CI: 1.24–15.76, <i>p</i> = 0.022). Cultural appropriateness of presence during childbirth (<i>p</i> = 0.039), male decision-making roles (<i>p</i> = 0.014), and openness in discussing pregnancy (<i>p</i> &lt; 0.001) showed significant associations with presence during childbirth.</p> Conclusion <p>Male involvement during labor is influenced by multiple social determinants, particularly income level, which emerged as the most significant predictor. Targeted interventions addressing educational gaps, economic barriers, and culturally sensitive approaches are needed to enhance male participation during childbirth.</p>