<p>Prior to the widespread availability of COVID-19 vaccines in 2021, the intent to vaccinate was a significant concern and subject of research. Misinformation about COVID-19 on the internet, often referred to as the "infodemic," was seen as a major impediment to vaccine acceptance. We compared the COVID-19 vaccine intent estimates from 2020 with the actual COVID-19 vaccine uptake and analyzed misinformation exposure levels in 46 countries. In 13 countries, vaccine uptake exceeds the initial intent by 5.98 to 23.61 percentage points. In 9 countries, intent and uptake are similar, while in 24 countries, uptake is lower than intent, ranging from -5.30 to -69.20 percentage points. All European and American countries are in the first category, whereas 20 of the 21 African countries are in the third. There is no direct association between misinformation exposure and the variation between intent and uptake. Increases are seen in countries with high misinformation exposure, while sharp decreases occur in countries with minimal exposure. COVID-19 misinformation does not seem to significantly impact vaccine uptake. Although misinformation may have influenced some people against vaccination, this was outweighed by those persuaded by accurate information. The primary determinant of vaccine uptake is the individual's assessment of their COVID-19 risk. People in European and American countries generally perceived this risk as high, in contrast to many in Africa, who deemed it low or nonexistent.</p>