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<p>The impact of HIV-associated stroke in Africa is an urgent public health challenge, with significant implications for individual well-being and healthcare systems across Africa. This review aims to elucidate the intricate relationship between Human Immunodeficiency Virus (HIV) and stroke, focusing on the epidemiology, risk factors, effects of antiretroviral therapy (ART), challenges and future directions of HIV-associated stroke in Africa. Persons living with HIV(PLWH) in Africa experience stroke decades earlier (32 to 43 years) than the median age (55 to 65 years) for stroke in the general population. Ischaemic stroke is commoner among PLWH in Africa, with a prevalence of 80–96%. The highest burden of HIV-associated stroke in Africa is seen in Eastern and Southern Africa (4.6 per 1000 person years). Untreated HIV itself, low socioeconomic status, low usage of ART, delay in commencement of combination antiretroviral therapy (cART) and long-term usage of cART increase the risk of stroke among PLWH in Africa. HIV-associated stroke among Africans is associated with a poorer prognosis, increased morbidity and mortality due to difficulties in determining the actual cause of the stroke and dearth in available diagnostic equipment and technology. In order to improve the outcomes and quality of life for individuals with HIV-associated stroke in Africa, there is a need to promote research collaborations in advancing our understanding of HIV-related stroke, as well as developing evidence-based interventions. Research findings can be translated into policy and practice by fostering partnerships, between academia, healthcare institutions and government agencies.</p>

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The burden of stroke among HIV population in Africa: a review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月12日

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  • Tejiri Napoleon,
  • Deborah Akinrinde,
  • Gbenga Joseph Alabi,
  • Chimuanya Eze,
  • Chioma Nnedinma Duru,
  • Oghogho Bazuaye,
  • Eleyinmi Oluwafunmilayo,
  • Ayomide Osungbade,
  • Ogedengbe Ifedolapo,
  • Okoye Chinwekene,
  • Cynthia Anyakudo,
  • Emmanuel Adesua,
  • Taofeek Olawoyin,
  • Glory Adebajo

摘要

The impact of HIV-associated stroke in Africa is an urgent public health challenge, with significant implications for individual well-being and healthcare systems across Africa. This review aims to elucidate the intricate relationship between Human Immunodeficiency Virus (HIV) and stroke, focusing on the epidemiology, risk factors, effects of antiretroviral therapy (ART), challenges and future directions of HIV-associated stroke in Africa. Persons living with HIV(PLWH) in Africa experience stroke decades earlier (32 to 43 years) than the median age (55 to 65 years) for stroke in the general population. Ischaemic stroke is commoner among PLWH in Africa, with a prevalence of 80–96%. The highest burden of HIV-associated stroke in Africa is seen in Eastern and Southern Africa (4.6 per 1000 person years). Untreated HIV itself, low socioeconomic status, low usage of ART, delay in commencement of combination antiretroviral therapy (cART) and long-term usage of cART increase the risk of stroke among PLWH in Africa. HIV-associated stroke among Africans is associated with a poorer prognosis, increased morbidity and mortality due to difficulties in determining the actual cause of the stroke and dearth in available diagnostic equipment and technology. In order to improve the outcomes and quality of life for individuals with HIV-associated stroke in Africa, there is a need to promote research collaborations in advancing our understanding of HIV-related stroke, as well as developing evidence-based interventions. Research findings can be translated into policy and practice by fostering partnerships, between academia, healthcare institutions and government agencies.