Objectives <p>This study aims to investigate the dissemination of obesity-related videos and the concept of “obesity is a chronic disease” on TikTok.</p> Methods <p>Videos with the hashtags “obesity”, “weight-loss” or those mentioning them in audio or subtitles were searched on TikTok and finally included to determine whether obesity was portrayed as predetermined frames.</p> Results <p>121 videos were included: 79 (65.3%) were published by physicians, 1 (0.8%) by hospitals, 3 (2.5%) by commercial weight-loss agencies, 31 (25.6%) by the general public, and 7 (5.8%) by others. Only 8 (6.6%) videos mentioned “obesity is a chronic disease” in the label frame, of which 6 videos were published by physicians, 1 by the general public, and 1 by a commercial weight loss agency. Included videos covered predetermined frames to varying degrees; the causes were the most mentioned (38.8%), followed by symptoms (32.2%), treatment (29.8%), obesity associated diseases (25.6%), diagnosis (17.4%), prevention (15.7%), and risk factors (9.9%). The included 121 videos have received 12,292,146 likes, 2,887,336 shares, and 837,814 comments since they were uploaded.</p> Conclusion <p>The content of short videos regarding obesity on TikTok was fragmented, and the concept of “obesity as a chronic disease” has not been well disseminated.</p>