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<p>The purpose of this study was to determine the relationship between the serum levels of kappa (κ) and lambda (λ) total light chain (TLC), the κ/λ ratio, and the combined serum TLCκ and TLCλ (ΣTLC) levels in Chinese centenarians and all-cause mortality. The association between serum TLC and all-cause mortality was investigated using restricted cubic spline (RCS) analysis, Cox proportional hazards models, and Kaplan‒Meier curves. The study included 906 centenarians (18.8% male), 838 (92.5%) of whom died during a median follow-up of 30 months. The proportions of centenarians with abnormal TLCκ and TLCλ levels were 68.1% and 49.0%, respectively. RCS analysis indicated that the levels of TLCκ, TLCλ, and ΣTLC were associated with all-cause mortality (<i>P</i> &lt; 0.05), whereas the κ/λ ratio was not (<i>P</i> &gt; 0.05). Cox proportional hazards analysis demonstrated that the highest quartiles of TLCκ, TLCλ, and ΣTLC were associated with an increased risk of death, with hazard ratios of 1.434 (95% confidence interval [CI], 1.061–1.939; <i>P</i> = 0.019), 1.351 (95% CI, 1.013–1.802; <i>P</i> = 0.041), and 1.891 (95% CI, 1.347–2.654; <i>P</i> &lt; 0.001), respectively. Kaplan–Meier analysis illustrated that centenarians with higher levels of TLCκ, TLCλ, and ΣTLC had significantly shorter median survival times (26 months versus 35 months, <i>P</i> &lt; 0.001; 26 months versus 32 months, <i>P</i> = 0.003; and 26 months versus 36 months, <i>P</i> &lt; 0.001, respectively). Our findings suggest that serum levels of TLCκ, TLCλ, and ΣTLC are significantly associated with all-cause mortality in centenarians.</p><p> <?noindent??><b>Trial registration</b> Not applicable.</p>

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Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月19日

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  • Yuting Duan,
  • Zhe Li,
  • Weiguang Zhang,
  • Yue Niu,
  • Bin Wang,
  • Zhe Feng,
  • Ding Sun,
  • Hao Li,
  • Zehao Zhang,
  • Zeyu Qu,
  • Qiushi Wang,
  • Xinye Jin,
  • Jie Zhang,
  • Miao Liu,
  • Hongyan Hu,
  • Yali Zhao,
  • Yao He,
  • Guangyan Cai,
  • Song Hu,
  • Xiangmei Chen,
  • Yizhi Chen

摘要

The purpose of this study was to determine the relationship between the serum levels of kappa (κ) and lambda (λ) total light chain (TLC), the κ/λ ratio, and the combined serum TLCκ and TLCλ (ΣTLC) levels in Chinese centenarians and all-cause mortality. The association between serum TLC and all-cause mortality was investigated using restricted cubic spline (RCS) analysis, Cox proportional hazards models, and Kaplan‒Meier curves. The study included 906 centenarians (18.8% male), 838 (92.5%) of whom died during a median follow-up of 30 months. The proportions of centenarians with abnormal TLCκ and TLCλ levels were 68.1% and 49.0%, respectively. RCS analysis indicated that the levels of TLCκ, TLCλ, and ΣTLC were associated with all-cause mortality (P < 0.05), whereas the κ/λ ratio was not (P > 0.05). Cox proportional hazards analysis demonstrated that the highest quartiles of TLCκ, TLCλ, and ΣTLC were associated with an increased risk of death, with hazard ratios of 1.434 (95% confidence interval [CI], 1.061–1.939; P = 0.019), 1.351 (95% CI, 1.013–1.802; P = 0.041), and 1.891 (95% CI, 1.347–2.654; P < 0.001), respectively. Kaplan–Meier analysis illustrated that centenarians with higher levels of TLCκ, TLCλ, and ΣTLC had significantly shorter median survival times (26 months versus 35 months, P < 0.001; 26 months versus 32 months, P = 0.003; and 26 months versus 36 months, P < 0.001, respectively). Our findings suggest that serum levels of TLCκ, TLCλ, and ΣTLC are significantly associated with all-cause mortality in centenarians.

Trial registration Not applicable.