Introduction <p>Dual contraception is the simultaneous prevention of unplanned pregnancy and sexually transmitted infections (STIs) using a non-barrier contraceptive method in conjunction with a barrier method. In this study, any female who had used a non-barrier contraceptive technique in conjunction with a barrier method within 12 months before the interview was considered to be using dual contraception. Dual contraception among high-risk populations, particularly young women, has not yet been well investigated, particularly in low- and middle-income regions. The purpose of this study was to assess the prevalence and factors related with dual contraceptive use among young women (18–25 years old) in Ntungamo municipality, southwestern Uganda.</p> Methods <p>This was a cross-sectional descriptive quantitative study of 499 young women aged 18 to 25 in Ntungamo municipality, Southwestern Uganda. A multistage sampling procedure was used to select two divisions, 12 wards, 20 cells, and 539 households. Participants were chosen at random from selected houses. A semi-structured questionnaire was utilized to collect information. The data was examined with SPSS version 20. Bivariate and multivariable logistic regression analyses were conducted, and <i>P</i> &lt; 0.05 was considered significant. The research and ethics commission (KABREC-2024-233) provided ethical approval, and all subjects gave their consent prior to recruitment. The study was conducted from September 2024 to March 2025.</p> Results <p>The prevalence of dual contraception was 24%. The most common method of dual contraception was condoms and injectable 59 (48.7%), condoms and contraceptive pills 34 (28%), condoms and implants 20 (16.5%). Factors associated with dual contraception included having more than three children (aOR = 4.55, 95% CI: 1.63–12.6, <i>p</i> = 0.004), no desire for children (aOR = 3.87, 95% CI:1.99–7.54, <i>p</i> = 0.001), a history of unintended pregnancies (aOR = 3.39, 95% CI:1.94–5.91, <i>p</i> = 0.001), having awareness of dual contraception (aOR = 3.96, 95% CI:2.39–6.56, <i>p</i> = 0.001), unaware of their partner’s HIV status (aOR = 2.32, 95% CI:1.32–4.06, <i>p</i> = 0.003) and having one sexual partner (aOR = 0.17, 95% CI:0.04–0.71, <i>p</i> = 0.015).</p> Conclusion <p>The unmet need for dual contraception still persists in Ntungamo Municipality, south western Uganda with only 24% uptake in this study. The most common methods used alongside condom were injectable contraceptives. Statistically significant factors associated with dual contraception were; having more than three children, no desire for children, history of unintended pregnancies, awareness about dual contraception, not knowing the partner’s HIV status and having only one sexual partner. There is need for more sensitisation of young women in southwestern Uganda and other rural communities in Low- and Middle-income communities to improve uptake of dual contraception. Male partner involvement may further improve uptake of dual contraception.</p>