Background <p>Endometriosis is a chronic, progressive, and recurrent condition affecting women of reproductive age. Its negative impact on intimate relationships and sexual function has been reported in a substantial proportion of affected women. This study aimed to explore experiences related to sexual function among women with endometriosis.</p> Methods <p>This qualitative study employed a content analysis approach. Participants included 12 women with endometriosis and 12 Healthcare providers (midwives, gynecologists, reproductive health specialists, psychiatrists, and psychologists) who were recruited through purposive sampling with maximum variation in Isfahan, Iran. Data were collected using in-depth individual interviews and field notes, and analyzed using the conventional qualitative content analysis method.</p> Results <p>Analysis of interview revealed six main categories including “neglect in addressing sexual dysfunction”, “effects of the disease and its treatment on marital life”, “sexual foresight”, “unmet needs and expectations”, “husband's experiences of sexual dysfunction” and “the spectrum of women's sexual dysfunction”.</p> Conclusions <p>The findings highlight the negative effects of endometriosis on multiple dimensions of sexual function and marital relationships in affected women and their spouses. Managing this condition requires a comprehensive and multi-dimensional approach that includes medical treatment, sexual counseling and education as well as psychological support for couples.</p>