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Objective <p>To describe the clinical characteristics, diagnostic findings, treatment, and outcomes of patients with Juvenile Idiopathic Arthritis (JIA) whose initial manifestation was cervical spine arthritis.</p> Methods <p>This retrospective multicenter study reviewed medical records of JIA patients who presented with cervical spine arthritis as the first and only symptom of the disease. Data collected included clinical presentation, imaging findings at diagnosis and follow-up, age at onset, JIA subtype, disease activity, treatment strategies, and clinical outcomes.</p> Results <p>Nine patients were identified, five of whom were classified as having oligoarticular-persistent JIA. The mean age at symptom onset was 4.98 ± 3.08 years, with an average diagnostic delay of 6.98 ± 9.78 months. The most common presenting symptom was torticollis (88.9%), followed by limited cervical range of motion (77.8%) and neck pain (55.6%). Cervical MRI was performed in all cases, demonstrating C1–C2 synovitis in every patient and subluxation in four. Initial treatments included nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and methotrexate. Seven patients required escalation to biologic therapy with tumor necrosis factor inhibitors (TNFi), and one underwent surgical arthrodesis.</p> Conclusions <p>Cervical spine arthritis may be the sole initial manifestation of JIA and should be considered in children with persistent torticollis. Early MRI evaluation is critical for timely diagnosis and monitoring. The frequent need for TNFi therapy highlights the potentially aggressive nature of this presentation and the importance of early recognition and intervention.</p>

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Cervical spine arthritis as initial manifestation in Juvenile Idiopathic Arthritis: a multicenter retrospective study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月10日

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  • Estefania Quesada-Masachs,
  • Jaime de Inocencio,
  • Juan Carlos Nieto González,
  • Indalecio Monteagudo Sáez,
  • Sara Murias Loza,
  • Marta Medrano San Ildefonso,
  • Joan Calzada Hernández,
  • Inmaculada Calvo Penadés,
  • Rocío Galindo Zabala,
  • Mireia Lopez Corbeto,
  • Jordi Antón

摘要

Objective

To describe the clinical characteristics, diagnostic findings, treatment, and outcomes of patients with Juvenile Idiopathic Arthritis (JIA) whose initial manifestation was cervical spine arthritis.

Methods

This retrospective multicenter study reviewed medical records of JIA patients who presented with cervical spine arthritis as the first and only symptom of the disease. Data collected included clinical presentation, imaging findings at diagnosis and follow-up, age at onset, JIA subtype, disease activity, treatment strategies, and clinical outcomes.

Results

Nine patients were identified, five of whom were classified as having oligoarticular-persistent JIA. The mean age at symptom onset was 4.98 ± 3.08 years, with an average diagnostic delay of 6.98 ± 9.78 months. The most common presenting symptom was torticollis (88.9%), followed by limited cervical range of motion (77.8%) and neck pain (55.6%). Cervical MRI was performed in all cases, demonstrating C1–C2 synovitis in every patient and subluxation in four. Initial treatments included nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and methotrexate. Seven patients required escalation to biologic therapy with tumor necrosis factor inhibitors (TNFi), and one underwent surgical arthrodesis.

Conclusions

Cervical spine arthritis may be the sole initial manifestation of JIA and should be considered in children with persistent torticollis. Early MRI evaluation is critical for timely diagnosis and monitoring. The frequent need for TNFi therapy highlights the potentially aggressive nature of this presentation and the importance of early recognition and intervention.