Disease activity at two consecutive registry visits and subsequent medication escalation for patients with juvenile idiopathic arthritis in the CARRA registry

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2025年7月22日

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Melissa L. Mannion,
Monica S. Aswani,
K. Ria Hearld,
Emily A. Smitherman,
Livie Timmerman,
Jeffrey R. Curtis,
R. Aamir,
K. Abulaban,
A. Adams,
C. Aguiar Lapsia,
H. Ahmed,
S. Akoghlanian,
A. AlBijadi,
E. Allenspach,
M. Alpizar,
G. Amarilyo,
M. Amoruso,
S. Angeles-Han,
S. Ardoin,
S. Armendariz,
N. Aviran Dagan,
I. Balboni,
S. Balevic,
S. Ballinger,
S. Baluta,
L. Barillas-Arias,
L. Barillas-Arias,
M. Basiaga,
K. Baszis,
M. Becker,
A. Begezda,
E. Beil,
H. Bell-Brunson,
H. Benham,
S. Benseler,
L. BermudezSantiago,
W. Bernal,
T. Bigley,
C. Bingham,
B. Binstadt,
C. Black,
B. Blackmon,
M. Blakley,
J. Bohnsack,
A. Boneparth,
H. Bradfield,
J. Bridges,
E. Brooks,
M. Brothers,
D. Brown,
H. Brunner,
L. Buckley,
Mary Buckley,
Meredith Buckley,
H. Bukulmez,
D. Bullock,
A. Cancino,
S. Canna,
L. Cannon,
S. Canny,
V. Cartwright,
E. Chalom,
Johanna Chang,
Joyce Chang,
M. Chang,
A. Chang-Hoftman,
A. Chen,
P. Chiraseveenuprapund,
K. Ciaglia,
M. Cidon,
D. Co,
E. Cohen,
R. Connor,
K. Cook,
A. Cooper,
J. Cooper,
K. Corbin,
C. Correll,
R. Cron,
M. Curry,
A. Dagci,
A. Dalrymple,
E. Datyner,
T. Davis,
D. De Ranieri,
J. Dean,
C. DeCoste,
F. Dedeoglu,
M. DeGuzman,
N. Delnay,
E. L. DeSantis,
R. Devine,
M. Dhalla,
A. Dhanrajani,
D. Dissanayake,
B. Dizon,
J. Drew,
K. Driest,
Q. Du,
E. Duncan,
K. Dunnock,
D. Durkee,
J. Dvergsten,
A. Eberhard,
K. Ede,
B. Edelheit,
C. Edens,
M. Elder,
Y. Elzaki,
C. Failing,
D. Fair,
L. Favier,
B. Feldman,
J. Fennell,
I. Ferguson,
P. Ferguson,
C. Figueroa,
E. Flanagan,
L. Fogel,
E. Fox,
M. Fox,
L. Franklin,
R. Fuhlbrigge,
J. Fuller,
T. Futch-West,
S. Gagne,
M. Geiszler,
D. Gerstbacher,
M. Gilbert,
A. C. Gironella,
D. Glaser,
I. Goh,
S. Gorry,
N. Goswami,
B. Gottlieb,
T. Graham,
S. Grevich,
T. Griffin,
A. Grim,
A. Grom,
M. Guevara,
L. Guzman,
T. Hahn,
O. Halyabar,
E. Hammelev,
T. Hammond,
S. Haro,
J. Harris,
O. Harry,
J. Hausmann,
A. Hay,
K. Hays,
K. Hayward,
L. Henderson,
M. Henrickson,
A. Hersh,
L. Hiraki,
M. Hiskey,
P. Hobday,
C. Hoffart,
M. J. Holland,
M. Hollander,
S. Hong,
D. Horton,
J. Hsu,
A. Huber,
J. Huggins,
J. Hui-Yuen,
M. Ibarra,
A. Imlay,
L. Imundo,
C. Inman,
A. Jackson,
K. James,
G. Janow,
Y. Jiang,
L. Johnson,
N. Johnson,
J. Jones,
D. Kafisheh,
K. Kaidar,
S. Kasinathan,
R. Kaur,
E. Kessler,
B. Kienzle,
S. Kim,
Y. Kimura,
D. Kingsbury,
M. Kitcharoensakkul,
J. Klauss,
K. Klein,
M. Klein-Gitelman,
A. Knight,
L. Kovalick,
D. Krajewski,
C. Kremer,
T. LaFlam,
B. Lang,
S. Lapidus,
B. Lapin,
A. Lasky,
E. Lawson,
R. Laxer,
A. Lee,
Patricia Lee,
Pui Lee,
T. Lee,
E. Leisinger,
L. Lentini,
M. Lerman,
Y. Levinsky,
D. Levy,
S. Li,
S. Lieberman,
L. Lim,
E. Limenis,
C. Lin,
N. Ling,
G. Lionetti,
R. Livny,
M. Lo,
A. Long,
M. Lopez-Peña,
D. Lovell,
S. Lvovich,
A. Lytch,
M. Ma,
A. Machado,
J. MacMahon,
J. Madison,
M. Mannion,
C. Manos,
L. Mansfield,
B. Marston,
K. Marzan,
T. Mason,
S. Matossian,
L. McAllister,
K. McBrearty,
D. McCurdy,
K. McDaniels,
J. McDonald,
L. McIntosh,
E. Meidan,
E. Mellins,
Z. Mian,
P. Miettunen,
M. Miller,
D. Milojevic,
R. Mitacek,
R. Modica,
S. Mohan,
K. Moore,
T. Moore,
L. Moorthy,
J. Moreno,
E. Morgan,
A. Moyer,
B. Murante,
A. Murphy,
E. Muscal,
O. Mwizerwa,
A. Najafi,
K. Nanda,
L. Nassi,
S. Nativ,
M. Natter,
J. Neely,
L. Newhall,
A. Nguyen,
P. Nigrovic,
J. Nocton,
B. Nolan,
A. Nowakowski,
K. Nowicki,
R. Oakes,
E. Oberle,
S. Ogbonnaya-Whittesley,
E. Ogbu,
M. Oliver,
R. Olveda,
K. Onel,
A. Orandi,
J. Padam,
N. Pan,
J. Pandya,
S. Panupattanapong,
A. Pappo Toledano,
J. Patel,
P. Patel,
A. Patrick,
S. Patrizi,
S. Paul,
J. Perfetto,
M. Perron,
M. Peskin,
C. Pinotti,
L. Ponder,
R. Pooni,
S. Prahalad,
M. Quinlan-Waters,
J. Rafko,
H. Rahimi,
S. Ramsey,
R. Randell,
L. Ray,
Ann Reed,
Annelle Reed,
H. Reid,
D. Reiff,
I. Reyhan,
B. Richard,
M. Riebschleger,
E. Rife,
M. Riskalla,
A. Robinson,
L. Robinson,
L. Rodgers,
M. Rodriquez,
D. Rogers,
T. Ronis,
A. Rosado,
M. Rosenkranz,
N. Rosenwasser,
H. Rothermel,
D. Rothman,
E. Rothschild,
K. Rouster - Stevens,
T. Rubinstein,
N. Ruth,
S. Sabbagh,
R. Sadun,
L. Santiago,
V. Saper,
A. Sarkissian,
L. Scalzi,
J. Schahn,
K. Schikler,
A. Schlefman,
B. Schlichting,
H. Schmeling,
E. Schmitt,
G. Schulert,
C. Schutt,
C. Seper,
B. Shaham,
R. Sheets,
A. Shehab,
S. Shenoi,
M. Sherman,
J. Shirley,
M. Shishov,
N. Singer,
V. Sivaraman,
E. Sloan,
C. Smith,
J. Smith,
E. Smitherman,
J. Soep,
M. B. Son,
C. Spencer,
L. Spiegel,
J. Spitznagle,
H. Srinivasalu,
H. Stapp,
A. Stephens,
Y. Sterba Rakovchik,
S. Stern,
B. Stevens,
R. Stevenson,
C. Stingl,
M. Stoll,
E. Stringer,
S. Sule,
J. Sullivan,
R. Sundel,
M. Sutter,
C. Swaffar,
N. Swayne,
T. Symington,
G. Syverson,
A. M. Szymanski,
S. Taber,
R. Tal,
A. Tambralli,
A. Taneja,
T. Tanner,
S. Tarvin,
A. Taxter,
M. Tesher,
T. Thakurdeen,
A. Theisen,
G. Thieroff,
B. Thomas,
L. Thomas,
N. Thomas,
L. Timmerman,
T. Ting,
C. Todd,
D. Toib,
K. Torok,
H. Tory,
M. Toth,
E. Treemarcki,
S. Tse,
T. Tse,
C. Tsin,
J. Twachtman-Bassett,
M. Twilt,
T. Valcarcel,
R. Valdovinos,
A. Vallee,
H. Van Mater,
S. Vandenbergen,
C. Varghese,
N. Vasquez,
P. Vega-Fernandez,
J. Verbsky,
R. Verstegen,
E. von Scheven,
S. Vora,
L. Wagner-Weiner,
D. Wahezi,
S. Wakefield,
B. Walker,
S. Wallgren,
H. Walters,
M. Waterfield,
J. Weiss,
P. Weiss,
E. Wershba,
V. Westheuser,
K. Widrick,
C. Williams,
S. Wong,
S. Wooldridge,
L. Woolnough,
T. Wright,
E. Wu,
A. Yalcindag,
R. Yeung,
K. Yomogida,
A. Zeft,
Y. J. Zhang,
Y. D. Zhao,
Z. Zheng,
A. Zhu,
C. Zic

摘要

Objective

To account for the chronic time course of juvenile idiopathic arthritis (JIA), we assessed medication changes by disease activity patterns across 2 sequential timepoints.

Methods

Patients with non-systemic JIA enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry with complete clinical Juvenile Arthritis Disease Activity Scores (cJADAS) at 6 and 12-month registry visits were included. Disease activity was classified by cJADAS categories (inactive/minimal, moderate/high). The primary outcome was disease modifying anti-rheumatic drug (DMARD) escalation at the 12-month visit. We examined the association between cJADAS patterns and DMARD escalation.

Results

The cJADAS patterns across paired visits for 2,956 patients with JIA were: 71% persistent inactive/minimal, 25% persistent moderate/high, 2% “improving”, and 2% “flaring”. Only 10% of patients had DMARD escalation at the 12-month visit, including only 15% of patients with persistent moderate/high disease activity. In multivariable logistic regression adjusting for sociodemographic and clinical variables, DMARD escalation at the 12-month visit was associated with “flaring” disease activity (odds ratio [OR] 2.62, 95% confidence interval [CI] 1.33–5.18), DMARD escalation between the 6- and 12-month visits (OR 1.86, 95% CI 1.40–2.49) and morning stiffness (> 60 min 4.98, 95% CI 3.00–8.27), while age 15–19 years were less likely to escalate (OR 0.61, 95% CI 0.38–0.97).

Conclusion

In a large multicenter registry of US patients with JIA, DMARD escalation at the 12-month visit was uncommon overall, even for those with persistent moderate/high disease activity. Our findings suggest that DMARD escalation in this cohort did not align well with a treat to target approach using cJADAS thresholds.