Scholarlink

Background <p>The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway serves as the core cytoplasmic DNA-sensing signaling pathway and represents a pivotal node within the immune-metabolic regulatory network through its coordination with mitochondrial metabolism.</p> Main body <p>Emerging evidence suggests that the cGAS-STING pathway plays a dual role in the tumor microenvironment (TME), promoting both anti-tumor immunity and tumor progression. These opposing effects are governed by the spatiotemporal dynamics of STING activation and the metabolic state of mitochondria. Recent studies have revealed that the clinical efficacy of STING agonists is constrained not only by the induction of chronic inflammatory responses but also by tumor metabolic heterogeneity. A comprehensive understanding of the mechanistic crosstalk between the cGAS-STING pathway and mitochondrial metabolism could provide a robust theoretical foundation for developing novel STING-targeted therapeutic strategies based on metabolic modulation.</p> Conclusion <p>This review provides a systematic overview of the interactive regulatory mechanisms connecting the cGAS-STING pathway with mitochondrial metabolism and assesses the translational potential of targeting this immune-metabolic axis in the context of precision oncology. The insights discussed herein are intended to support the rational optimization and clinical application of STING agonists.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The cGAS-STING pathway and mitochondrial metabolism: from mechanistic insights to therapeutic potential in tumor

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月30日

查看全文
  • Kui Zhao,
  • Siyuan Cui,
  • Na Wang,
  • Qi Wei,
  • Xuerui Wang,
  • Ke Hou,
  • Jinli Zhu,
  • Fanming Kong

摘要

Background

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway serves as the core cytoplasmic DNA-sensing signaling pathway and represents a pivotal node within the immune-metabolic regulatory network through its coordination with mitochondrial metabolism.

Main body

Emerging evidence suggests that the cGAS-STING pathway plays a dual role in the tumor microenvironment (TME), promoting both anti-tumor immunity and tumor progression. These opposing effects are governed by the spatiotemporal dynamics of STING activation and the metabolic state of mitochondria. Recent studies have revealed that the clinical efficacy of STING agonists is constrained not only by the induction of chronic inflammatory responses but also by tumor metabolic heterogeneity. A comprehensive understanding of the mechanistic crosstalk between the cGAS-STING pathway and mitochondrial metabolism could provide a robust theoretical foundation for developing novel STING-targeted therapeutic strategies based on metabolic modulation.

Conclusion

This review provides a systematic overview of the interactive regulatory mechanisms connecting the cGAS-STING pathway with mitochondrial metabolism and assesses the translational potential of targeting this immune-metabolic axis in the context of precision oncology. The insights discussed herein are intended to support the rational optimization and clinical application of STING agonists.