Scholarlink

Background <p>Exercise-derived extracellular vesicles (ExEVs) have emerged as pivotal mediators of the systemic benefits associated with physical activity (PA). Growing evidence highlights their involvement in modulating cancer biology, enhancing immune surveillance, and alleviating treatment-related toxicity.</p> Main body <p>Recent preclinical studies have begun to unravel the molecular composition and functional characteristics of ExEVs, suggesting considerable potential as both biomarkers and therapeutic agents in oncology and cardio-oncology. There is also increasing interest in the development of extracellular vesicle-inspired nanotherapeutics, with the goal of replicating the anticancer and cardioprotective benefits observed with PA in patients with cancer. While these approaches show promise, significant translational challenges persist, including heterogeneity among vesicle populations, manufacturing complexities, and unresolved regulatory questions.</p> Conclusions <p>To address these barriers, a coordinated strategy is necessary. This should include the establishment of standardized protocols, promotion of interdisciplinary collaboration, and integration with personalized oncology frameworks. Progress in the therapeutic application of ExEVs may ultimately facilitate the development of innovative, low-toxicity interventions for cancer care.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Exercise-derived extracellular vesicles in oncology: a new frontier for translational nanomedicine

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月28日

查看全文
  • Monica Silvestri,
  • Cristina Fantini,
  • Guglielmo Duranti,
  • Elisa Grazioli,
  • Daniela Caporossi,
  • Carolina Balbi,
  • Ivan Dimauro

摘要

Background

Exercise-derived extracellular vesicles (ExEVs) have emerged as pivotal mediators of the systemic benefits associated with physical activity (PA). Growing evidence highlights their involvement in modulating cancer biology, enhancing immune surveillance, and alleviating treatment-related toxicity.

Main body

Recent preclinical studies have begun to unravel the molecular composition and functional characteristics of ExEVs, suggesting considerable potential as both biomarkers and therapeutic agents in oncology and cardio-oncology. There is also increasing interest in the development of extracellular vesicle-inspired nanotherapeutics, with the goal of replicating the anticancer and cardioprotective benefits observed with PA in patients with cancer. While these approaches show promise, significant translational challenges persist, including heterogeneity among vesicle populations, manufacturing complexities, and unresolved regulatory questions.

Conclusions

To address these barriers, a coordinated strategy is necessary. This should include the establishment of standardized protocols, promotion of interdisciplinary collaboration, and integration with personalized oncology frameworks. Progress in the therapeutic application of ExEVs may ultimately facilitate the development of innovative, low-toxicity interventions for cancer care.