Scholarlink

<p>Micropeptides are small peptide chains translated from non-coding RNAs (<i>ncRNAs</i>), typically ranging from &lt; 100 to ~ 200 amino acids in length, and usually encoded by short or small open reading frames (<i>sORFs/smORFs</i>). Recent advances in high-throughput sequencing and multi-omics technologies have enabled genome-wide identification of <i>sORFs</i> across diverse species. Notably, a subset of these <i>sORFs</i> encodes functional micropeptides that play critical roles in biological processes such as inflammation, metabolism, and tumorigenesis. Emerging evidence suggests that tumor-associated micropeptides regulate key hallmarks of cancer, including proliferation, metastasis, metabolic reprogramming, angiogenesis, ion homeostasis, and immune evasion. In this review, we define the definition of micropeptides and discuss cutting-edge methodologies for their discovery, such as ribosome profiling (Ribo-seq), mass spectrometry (MS), and <i>sORF</i>-centric bioinformatics pipelines. Furthermore, we systematically summarize the functional mechanisms of micropeptides in tumor initiation, progression, therapeutic response, and drug resistance. This synthesis aims to provide novel perspectives on cancer biology and highlights micropeptides promising candidates for use as diagnostic biomarkers and targeted therapies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Micropeptides in the oncological dark matter: decoding their roles in tumor progression and therapy resistance

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月25日

查看全文
  • Qiqi Zhang,
  • Haian Yang,
  • Chunhua Wang,
  • Diabate Ousmane,
  • Jie Liu,
  • Ziyu Liu,
  • Wangrui Liu,
  • Yuanliang Yan,
  • Zhijie Xu,
  • Junpu Wang

摘要

Micropeptides are small peptide chains translated from non-coding RNAs (ncRNAs), typically ranging from < 100 to ~ 200 amino acids in length, and usually encoded by short or small open reading frames (sORFs/smORFs). Recent advances in high-throughput sequencing and multi-omics technologies have enabled genome-wide identification of sORFs across diverse species. Notably, a subset of these sORFs encodes functional micropeptides that play critical roles in biological processes such as inflammation, metabolism, and tumorigenesis. Emerging evidence suggests that tumor-associated micropeptides regulate key hallmarks of cancer, including proliferation, metastasis, metabolic reprogramming, angiogenesis, ion homeostasis, and immune evasion. In this review, we define the definition of micropeptides and discuss cutting-edge methodologies for their discovery, such as ribosome profiling (Ribo-seq), mass spectrometry (MS), and sORF-centric bioinformatics pipelines. Furthermore, we systematically summarize the functional mechanisms of micropeptides in tumor initiation, progression, therapeutic response, and drug resistance. This synthesis aims to provide novel perspectives on cancer biology and highlights micropeptides promising candidates for use as diagnostic biomarkers and targeted therapies.