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Background <p>Invasive ductal carcinoma of the breast most commonly metastasizes to bone, lung, liver, and central nervous system. Breast cancer metastasis to the gallbladder is exceptionally rare, especially when it is secondary to breast cancer of ductal origin.</p> Case presentation <p>We present the case of a pre-menopausal 43-year-old female with a history of major depressive disorder and no prior mammograms who was diagnosed with ER+/PR+/HER2+ invasive ductal carcinoma of the right breast. She developed late metastasis to the gallbladder, liver, lung and bone detected four years after breast conserving surgery with delayed neoadjuvant chemotherapy, adjuvant radiation, incomplete adjuvant biologic and hormone therapy, and lack of surveillance. The patient died three years and ten months after her lumpectomy. </p> Conclusions <p>Though rare, adequate suspicion should be maintained when evaluating patients with a history of breast cancer who present with symptoms of cholecystitis or biliary colic in order to promptly identify breast cancer metastasis to the gallbladder, as well as to more common metastatic sites.</p>

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Invasive ductal carcinoma of the breast with gallbladder metastasis: a rare case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月13日

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  • Kendall Vignaroli,
  • Kevin Perez,
  • Michelle Lee,
  • Sharmila Raju,
  • Alex Nguyen,
  • Aldin Malkoc,
  • Ella Martinetto,
  • Ruben Burbank,
  • Ahmad Ibrahim,
  • Ellen Ko,
  • Judi Anne B. Ramiscal

摘要

Background

Invasive ductal carcinoma of the breast most commonly metastasizes to bone, lung, liver, and central nervous system. Breast cancer metastasis to the gallbladder is exceptionally rare, especially when it is secondary to breast cancer of ductal origin.

Case presentation

We present the case of a pre-menopausal 43-year-old female with a history of major depressive disorder and no prior mammograms who was diagnosed with ER+/PR+/HER2+ invasive ductal carcinoma of the right breast. She developed late metastasis to the gallbladder, liver, lung and bone detected four years after breast conserving surgery with delayed neoadjuvant chemotherapy, adjuvant radiation, incomplete adjuvant biologic and hormone therapy, and lack of surveillance. The patient died three years and ten months after her lumpectomy.

Conclusions

Though rare, adequate suspicion should be maintained when evaluating patients with a history of breast cancer who present with symptoms of cholecystitis or biliary colic in order to promptly identify breast cancer metastasis to the gallbladder, as well as to more common metastatic sites.