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<p>Chordoid meningioma (CM) is an uncommon histological variant of meningioma, typically found intracranially. Intraspinal occurrences, particularly in the cervical region, are exceedingly rare. We report a unique case of a 73-year-old male with cervical spinal CM who experienced tumor recurrence two years after gross total resection (GTR). Histopathological analysis confirmed the recurrence as anaplastic meningioma with telomerase reverse transcriptase (TERT) promoter C250T mutation, CNS WHO Grade 3—marking the first documented association of this mutation with spinal CM. This case underscores the diagnostic, molecular, and prognostic complexities of spinal CM and highlights the critical role of TERT promoter mutation in tumor behavior and classification.</p>

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TERT promoter C250T mutation in a recurrent cervical chordoid meningioma: a unique case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月26日

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  • Xuanbo Shao,
  • Zhuofan Xu,
  • Penghao Liu,
  • Teng Zhang,
  • Yang Feng,
  • Shaxi Zhu,
  • Zan Chen,
  • Wanru Duan

摘要

Chordoid meningioma (CM) is an uncommon histological variant of meningioma, typically found intracranially. Intraspinal occurrences, particularly in the cervical region, are exceedingly rare. We report a unique case of a 73-year-old male with cervical spinal CM who experienced tumor recurrence two years after gross total resection (GTR). Histopathological analysis confirmed the recurrence as anaplastic meningioma with telomerase reverse transcriptase (TERT) promoter C250T mutation, CNS WHO Grade 3—marking the first documented association of this mutation with spinal CM. This case underscores the diagnostic, molecular, and prognostic complexities of spinal CM and highlights the critical role of TERT promoter mutation in tumor behavior and classification.