Scholarlink

Objective <p>To investigate the relationship of pretreatment of circulating tumor cells (CTCs) and cervical lymph node metastasis (LNM) (central LNM (CLNM) and lateral LNM (LLNM)) in papillary thyroid carcinoma (PTC) patients with ≤ 55 years old.</p> Methods <p>Clinicopathological data (CTCs level, Hashimoto’s thyroiditis, thyroid function, multifocal, tumor size, invaded capsule, clinical stage, and LNM) of 588 PTC patients with ≤ 55 years old were retrospectively collected. The relationship of CLNM, LLNM and the clinical features of patients was analyzed. Univariate and multivariate logistic regression analyses were used to evaluate the relationship between the CTCs and CLNM, LLNM.</p> Results <p>There were 273(46.4%) and 89(15.1%) patients with CLNM and LLNM, respectively. Patients with CLNM had higher proportions of multifocality, tumor size &gt; 1&#xa0;cm, invaded capsule, and positive CTCs level than those without (all <i>p</i> &lt; 0.05). Patients with LLNM had higher proportions of multifocality, tumor size &gt; 1&#xa0;cm, and invaded capsule than those without (all <i>p</i> &lt; 0.05). Logistic regression analysis showed that multifocality (odds ratio (OR): 1.821, 95% confidence interval (CI): 1.230–2.698, <i>p</i> = 0.003), tumor size &gt; 1&#xa0;cm (OR: 3.444, 95% CI: 2.296–5.167, <i>p</i> &lt; 0.001), invaded capsule (OR: 1.699, 95% CI: 1.167–2.473, <i>p</i> = 0.006), and positive CTCs level (OR: 1.469, 95% CI: 1.019–2.118, <i>p</i> = 0.040) were independently associated with CLNM; and multifocality (OR: 2.373, 95% CI: 1.389–4.052, <i>p</i> = 0.002), tumor size &gt; 1&#xa0;cm (OR: 5.344, 95% CI: 3.037–9.402, <i>p</i> &lt; 0.001), and invaded capsule (OR: 2.591, 95% CI: 1.436–4.674, <i>p</i> = 0.002) were independently associated with LLNM.</p> Conclusions <p>Preoperative CTCs positive was associated with CLNM in PTC patients with ≤ 55 years old, but not LLNM.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pretreatment level of circulating tumor cells is associated with lymph node metastasis in papillary thyroid carcinoma patients with ≤ 55 years old

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月29日

查看全文
  • Ming Yu,
  • Jiaqin Deng,
  • Yihua Gu,
  • Yeqian Lai,
  • Yuedong Wang

摘要

Objective

To investigate the relationship of pretreatment of circulating tumor cells (CTCs) and cervical lymph node metastasis (LNM) (central LNM (CLNM) and lateral LNM (LLNM)) in papillary thyroid carcinoma (PTC) patients with ≤ 55 years old.

Methods

Clinicopathological data (CTCs level, Hashimoto’s thyroiditis, thyroid function, multifocal, tumor size, invaded capsule, clinical stage, and LNM) of 588 PTC patients with ≤ 55 years old were retrospectively collected. The relationship of CLNM, LLNM and the clinical features of patients was analyzed. Univariate and multivariate logistic regression analyses were used to evaluate the relationship between the CTCs and CLNM, LLNM.

Results

There were 273(46.4%) and 89(15.1%) patients with CLNM and LLNM, respectively. Patients with CLNM had higher proportions of multifocality, tumor size > 1 cm, invaded capsule, and positive CTCs level than those without (all p < 0.05). Patients with LLNM had higher proportions of multifocality, tumor size > 1 cm, and invaded capsule than those without (all p < 0.05). Logistic regression analysis showed that multifocality (odds ratio (OR): 1.821, 95% confidence interval (CI): 1.230–2.698, p = 0.003), tumor size > 1 cm (OR: 3.444, 95% CI: 2.296–5.167, p < 0.001), invaded capsule (OR: 1.699, 95% CI: 1.167–2.473, p = 0.006), and positive CTCs level (OR: 1.469, 95% CI: 1.019–2.118, p = 0.040) were independently associated with CLNM; and multifocality (OR: 2.373, 95% CI: 1.389–4.052, p = 0.002), tumor size > 1 cm (OR: 5.344, 95% CI: 3.037–9.402, p < 0.001), and invaded capsule (OR: 2.591, 95% CI: 1.436–4.674, p = 0.002) were independently associated with LLNM.

Conclusions

Preoperative CTCs positive was associated with CLNM in PTC patients with ≤ 55 years old, but not LLNM.