Background <p>Chemotherapy induced peripheral neuropathy (CIPN) is a symptom commonly reported by pediatric oncology patients who receive neurotoxicity agents. Early identification is imperative for the intervention implementation. Currently, the Pediatric Chemotherapy-Induced Neuropathy (P-CIN) is an age-appropriate, patient-reported outcome (PRO) for pediatric CIPN. However, it has not been used in China, and importantly does not contain a cut-off value to guide healthcare professionals for clinical decision making.</p> Objectives <p>We aimed to cross-cultural adapt the P-CIN into Chinese context, and assess its psychometric properties.</p> Design <p>Methodological and descriptive study.</p> Settings <p>Shenzhen Children’s Hospital, Henan Cancer Hospital and Shanghai Children’s Medical Center in China.</p> Participants <p>313 pediatric oncology patients were conveniently sampled.</p> Methods <p>The Chinese P-CIN version was cross-culturally adapted and validated according to the established methodological guidelines. Participants were asked to provide demographic and clinical information, complete the translated P-CIN, Wong-baker FACES Pain Rating scale, and Pediatric Quality of Life Inventory (PedsQL) Cancer Module, and nerve conduction study.</p> Results <p>The Chinese P-CIN version showed satisfactory internal consistency (Cronbach’s alpha coefficient: 0.771) and good test-retest reliability for 2-week interval (intraclass correlation coefficient: 0.810). Excellent content validity was demonstrated; the item content validity index (CVI) ranged from 0.90 to 1.00, the average-CVI was 0.98 and the universal-CVI was 0.85. The total score of the translated P-CIN was strongly correlated with the Wong-baker FACES Pain Rating scale (Spearman’s correlation coefficient (r): 0.909, <i>p</i> &lt; 0.001) and PedsQL Cancer Module (<i>r</i> = -0.710, <i>p</i> &lt; 0.001), presenting good convergent validity. Using the clinician diagnosis of pediatric CIPN as a reference criterion, the area under the curve was 0.894. The optimal cut-off value to identify significant symptom burden of CIPN was 9. Exploratory factor analysis yielded a two-factor model (Sensory symptoms and Functional Task Performance Ability). The confirmatory factor analysis results supported the good fit of the two-factor model. Known-group validity was supported by the significant differences in the translated P-CIN score between patients grouped by neurotoxic chemotherapy agents (<i>p</i> = 0.014, η_p²=0.019) and cancer diagnosis (<i>p</i> = 0.026, η_p²=0.016). Besides, 82% of the participants completed the translated P-CIN independently.</p> Conclusions <p>The Chinese P-CIN version was found to be a reliable and feasible PRO for pediatric CIPN. It shall be adopted as a routine tool for the detection of CIPN among Chinese pediatric oncology patients.</p> Registration <p>Clinicaltrial, NCT07053579. Registered 18/06/2025, retrospectively registered.</p>