Scholarlink

Background <p>Liver fibrosis represents a critical pathological process in chronic liver disease for which precision therapies remain limited.</p> Results <p>Here we report a biomimetic nanodrug (RAET NPs) that integrates a reactive oxygen species (ROS)-responsive prodrug of acetate gossypol with hybrid cell membrane camouflage and aptamer-mediated targeting. RAET NPs are constructed through modular assembly: the ROS-responsive prodrug core is encapsulated within a hybrid membrane shell formed by fusing activated hepatic stellate cell (HSC)-derived exosome membranes with M1-type macrophage membranes, followed by decoration with CD44-specific nucleic acid aptamers. This design preserves the full repertoire of membrane-associated targeting proteins while incorporating synthetic aptamers for enhanced recognition specificity. Meanwhile, RAET NPs remain in an inert state under normal physiological conditions to reduce biotoxicity and are converted into active drugs only in the fibrosis-induced reactive oxygen species (ROS)-rich microenvironment, enabling controlled drug release at the lesion site. In both organoid and animal models of liver fibrosis, RAET NPs suppress HSC activation and extracellular matrix deposition, significantly attenuating disease progression.</p> Conclusions <p>This biomimetic nanomedicine offers a novel strategy for precision treatment of liver fibrosis through the synergistic function of prodrug and biomimetic delivery.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Chemically programmable hybrid membrane-camouflaged acetate gossypol prodrug reprograms the hepatic microenvironment for the treatment of liver fibrosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月31日

查看全文
  • Mingming Song,
  • Ying Fang,
  • Xiaqing Gong,
  • Jiandong Wang,
  • Han Yuan,
  • Kai Wang,
  • Xiaowen Yu,
  • Jihui Tang

摘要

Background

Liver fibrosis represents a critical pathological process in chronic liver disease for which precision therapies remain limited.

Results

Here we report a biomimetic nanodrug (RAET NPs) that integrates a reactive oxygen species (ROS)-responsive prodrug of acetate gossypol with hybrid cell membrane camouflage and aptamer-mediated targeting. RAET NPs are constructed through modular assembly: the ROS-responsive prodrug core is encapsulated within a hybrid membrane shell formed by fusing activated hepatic stellate cell (HSC)-derived exosome membranes with M1-type macrophage membranes, followed by decoration with CD44-specific nucleic acid aptamers. This design preserves the full repertoire of membrane-associated targeting proteins while incorporating synthetic aptamers for enhanced recognition specificity. Meanwhile, RAET NPs remain in an inert state under normal physiological conditions to reduce biotoxicity and are converted into active drugs only in the fibrosis-induced reactive oxygen species (ROS)-rich microenvironment, enabling controlled drug release at the lesion site. In both organoid and animal models of liver fibrosis, RAET NPs suppress HSC activation and extracellular matrix deposition, significantly attenuating disease progression.

Conclusions

This biomimetic nanomedicine offers a novel strategy for precision treatment of liver fibrosis through the synergistic function of prodrug and biomimetic delivery.

Graphical Abstract