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<p>Diabetic foot ulcers have become an increasingly serious clinical problem, in which wound pH dysregulation and infection lead to impaired healing. To improve this situation, we propose a fabric coated with a binary hydrogen-bonded organic framework (SMU-8@W) to enhance wound healing efficiency. Specifically, the hydrogen-bonded organic framework (SMU-8) not only suppresses wound infection through its high photodynamic activity but also guides a “near-neutral-weakly acidic-near-neutral” pH transition at the wound site, thereby modulating the wound microenvironment. Moreover, SMU-8@W exhibits favorable hemostatic performance (BCI = 21.19 ± 2.52%), moisture permeability (5874.20 ± 196.03&#xa0;g·m⁻²·d⁻¹), biosafety, and long-term stability, effectively managing wound exudate and alleviating inflammation, thereby accelerating wound healing. In summary, SMU-8@W offers a pH-modulating, infection-suppressing, angiogenesis-promoting, and collagen-enhancing therapeutic strategy for diabetic foot ulcers.</p> Graphical Abstract <p></p>

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pH-modulating binary hydrogen-bonded organic frameworks accelerate diabetic wound healing

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月22日

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  • Junpeng Sun,
  • Xiang Sun,
  • Mei Xia,
  • Qianjun Xiao,
  • Kaikai Ma,
  • Zike Liao,
  • Guanglai Mo,
  • Xiaoying Li,
  • Luying Lai,
  • Haihao Huang,
  • Chunhui Cui,
  • Peng Li,
  • Xiaopin Duan,
  • Jisheng Xiao

摘要

Diabetic foot ulcers have become an increasingly serious clinical problem, in which wound pH dysregulation and infection lead to impaired healing. To improve this situation, we propose a fabric coated with a binary hydrogen-bonded organic framework (SMU-8@W) to enhance wound healing efficiency. Specifically, the hydrogen-bonded organic framework (SMU-8) not only suppresses wound infection through its high photodynamic activity but also guides a “near-neutral-weakly acidic-near-neutral” pH transition at the wound site, thereby modulating the wound microenvironment. Moreover, SMU-8@W exhibits favorable hemostatic performance (BCI = 21.19 ± 2.52%), moisture permeability (5874.20 ± 196.03 g·m⁻²·d⁻¹), biosafety, and long-term stability, effectively managing wound exudate and alleviating inflammation, thereby accelerating wound healing. In summary, SMU-8@W offers a pH-modulating, infection-suppressing, angiogenesis-promoting, and collagen-enhancing therapeutic strategy for diabetic foot ulcers.

Graphical Abstract