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<p>The deep-seated locations and hypoxic microenvironments of tumors critically hinder conventional phototherapies. To overcome these limitations, we engineered a novel Au@Cu<sub>2 − x</sub>Se nanoprobe via precise aspect ratio control of gold nanorods for NIR-II plasmonic resonance and site-specific growth of Cu<sub>2 − x</sub>Se domains, resulting in the formation of a unique “lollipop” nanostructure. This design enables single-wavelength NIR-II laser-activated photothermal therapy and dynamic dual-modal therapy with intrinsic hypoxia tolerance: the nanoprobes achieve exceptional photothermal stability while simultaneously driving photothermally enhanced chemodynamic activity through accelerated Fenton-like catalytic cycles. Crucially, this strategy not only eradicates deep tumors but also activates systemic antitumor immunity. Combined with real-time photoacoustic imaging guidance, the platform establishes an oxygen-independent paradigm for treating hypoxic solid tumors.</p> Graphical Abstract <p></p>

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A highly photothermal stability Au@Cu2 − xSe nanoprobe for photoacoustic-imaging guided dual enhanced NIR- II photothermal/chemodynamic therapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月16日

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  • Bei Li,
  • Zhengqiang Chen,
  • Yong Sun,
  • Maling Gou,
  • Yuting Luo,
  • Wenli Zhang,
  • Xiwen Ye,
  • Yaqin Zhao,
  • Lei Feng,
  • Zhen You

摘要

The deep-seated locations and hypoxic microenvironments of tumors critically hinder conventional phototherapies. To overcome these limitations, we engineered a novel Au@Cu2 − xSe nanoprobe via precise aspect ratio control of gold nanorods for NIR-II plasmonic resonance and site-specific growth of Cu2 − xSe domains, resulting in the formation of a unique “lollipop” nanostructure. This design enables single-wavelength NIR-II laser-activated photothermal therapy and dynamic dual-modal therapy with intrinsic hypoxia tolerance: the nanoprobes achieve exceptional photothermal stability while simultaneously driving photothermally enhanced chemodynamic activity through accelerated Fenton-like catalytic cycles. Crucially, this strategy not only eradicates deep tumors but also activates systemic antitumor immunity. Combined with real-time photoacoustic imaging guidance, the platform establishes an oxygen-independent paradigm for treating hypoxic solid tumors.

Graphical Abstract