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Background <p>China has a large population, and the prevalence of dyslipidemia varies across regions. The prevalence of dyslipidemia is closely associated with the increasing burden of cardiovascular disease. Currently, there is a lack of high-quality data on early-onset dyslipidemia in Northwest China. This study aims to comprehensively assess the prevalence and risk factors of early-onset dyslipidemia among adults in this region, providing epidemiological evidence for disease prevention and health promotion.</p> Methods <p>This is a cross-sectional study based on the universal health check-up program conducted in northwestern China from January to December 2019. Adults (aged 18 to 65 years old) living in both rural and urban areas were included. Participants received a questionnaire survey, physical examination, and laboratory tests, including liver and kidney function, complete blood count, fasting blood glucose, and lipid profile.</p> Result <p>This study included a total of 3,559,141 participants (43.2% male and 56.8% female). The prevalence of early-onset dyslipidemia was 25.7%, with hypercholesterolemia accounting for 3.6%, hypertriglyceridemia for 10.6%, elevated low-density lipoprotein cholesterol for 2.7%, and reduced high-density lipoprotein cholesterol for 14.5%. Abnormalities in a single lipid parameter were observed in 20.5% of participants, while abnormalities in two, three, and four lipid parameters were observed in 4.6%, 0.6%, and 0.1% of participants, respectively. Male sex, age, diabetes, hypertension, smoking, alcohol consumption, and overweight/obesity were all significant risk factors for early-onset dyslipidemia.</p> Conclusion <p>The age-standardized prevalence of early-onset dyslipidemia and its subtypes in Northwest China remains lower than the national level. Existing evidence consistently indicates that males, advancing age, diabetes, hypertension, smoking, alcohol consumption, and overweight/obesity are independent risk factors for early-onset dyslipidemia. Therefore, systematic screening should be initiated for this population (&lt; 40 years old), with stratified management involving enhanced lifestyle interventions combined with evidence-based lipid-lowering medications.</p>

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Prevalence and risk factor analysis of early-onset dyslipidemia-a cross-sectional study of 3.7 million population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月23日

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  • Fen Liu,
  • Liting Cai,
  • Qian Zhao,
  • Jing Tao,
  • Yaoguo Wang,
  • Juan Wang,
  • Deyang Li,
  • Junqing Xie,
  • Xiaomei Li,
  • Yining Yang

摘要

Background

China has a large population, and the prevalence of dyslipidemia varies across regions. The prevalence of dyslipidemia is closely associated with the increasing burden of cardiovascular disease. Currently, there is a lack of high-quality data on early-onset dyslipidemia in Northwest China. This study aims to comprehensively assess the prevalence and risk factors of early-onset dyslipidemia among adults in this region, providing epidemiological evidence for disease prevention and health promotion.

Methods

This is a cross-sectional study based on the universal health check-up program conducted in northwestern China from January to December 2019. Adults (aged 18 to 65 years old) living in both rural and urban areas were included. Participants received a questionnaire survey, physical examination, and laboratory tests, including liver and kidney function, complete blood count, fasting blood glucose, and lipid profile.

Result

This study included a total of 3,559,141 participants (43.2% male and 56.8% female). The prevalence of early-onset dyslipidemia was 25.7%, with hypercholesterolemia accounting for 3.6%, hypertriglyceridemia for 10.6%, elevated low-density lipoprotein cholesterol for 2.7%, and reduced high-density lipoprotein cholesterol for 14.5%. Abnormalities in a single lipid parameter were observed in 20.5% of participants, while abnormalities in two, three, and four lipid parameters were observed in 4.6%, 0.6%, and 0.1% of participants, respectively. Male sex, age, diabetes, hypertension, smoking, alcohol consumption, and overweight/obesity were all significant risk factors for early-onset dyslipidemia.

Conclusion

The age-standardized prevalence of early-onset dyslipidemia and its subtypes in Northwest China remains lower than the national level. Existing evidence consistently indicates that males, advancing age, diabetes, hypertension, smoking, alcohol consumption, and overweight/obesity are independent risk factors for early-onset dyslipidemia. Therefore, systematic screening should be initiated for this population (< 40 years old), with stratified management involving enhanced lifestyle interventions combined with evidence-based lipid-lowering medications.