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Background <p>Venous thromboembolism is a serious complication in older fracture patients. While triglyceride levels are established cardiovascular risk factors, their role in venous thrombosis remains controversial, with inconsistent associations reported in general populations.</p> Methods <p>A retrospective cross-sectional analysis was conducted on 522 older (≥75 years) fracture patients hospitalized in Kunshan, China (2017–2023). Lower-extremity venous thrombosis was assessed via ultrasonography, with serum triglycerides measured within 24&#xa0;h of admission. Participants were categorized based on triglyceride tertiles for comparative analysis. Analyses were adjusted for demographics and clinical variables. Non-linear relationships were assessed through threshold effect analyses.</p> Results <p>Lower-extremity thrombosis prevalence differed significantly across triglyceride tertiles (low: 9.30%, middle: 10.05%, high: 18.63%; <i>p</i> = 0.02). A significant threshold effect was observed at 1.48 mmol/L, below which increased triglyceride levels were significantly associated with higher thrombosis risk (β = 3.38, 95% CI: 1.10-10.41, <i>p</i> = 0.03). This relationship was not apparent above 1.48 mmol/L (β = 0.49, 95% CI: 0.16–1.58, <i>p</i> = 0.23). Stratified analyses confirmed this non-linear association across subgroups.</p> Conclusion <p>Serum triglyceride levels exhibited a significant non-linear association with venous thrombosis risk in older Chinese fracture patients. Patients with triglyceride levels below 1.48 mmol/L may represent a vulnerable subgroup with increased thrombosis risk, suggesting the potential utility of triglyceride measurements for refined risk stratification and personalized thrombosis prophylaxis.</p>

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Association between serum triglyceride levels and venous thrombosis risk in older Chinese patients with fractures: a retrospective cross-sectional study

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  • 发表日期：

    2025年9月26日

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  • Ya-qin Gong,
  • Shao-han Guo,
  • Zhou-hang Liu,
  • Jian Xu,
  • Cong Wang,
  • Lei-you Zhou,
  • Jian Jin,
  • Chong Li,
  • Ke Lu

摘要

Background

Venous thromboembolism is a serious complication in older fracture patients. While triglyceride levels are established cardiovascular risk factors, their role in venous thrombosis remains controversial, with inconsistent associations reported in general populations.

Methods

A retrospective cross-sectional analysis was conducted on 522 older (≥75 years) fracture patients hospitalized in Kunshan, China (2017–2023). Lower-extremity venous thrombosis was assessed via ultrasonography, with serum triglycerides measured within 24 h of admission. Participants were categorized based on triglyceride tertiles for comparative analysis. Analyses were adjusted for demographics and clinical variables. Non-linear relationships were assessed through threshold effect analyses.

Results

Lower-extremity thrombosis prevalence differed significantly across triglyceride tertiles (low: 9.30%, middle: 10.05%, high: 18.63%; p = 0.02). A significant threshold effect was observed at 1.48 mmol/L, below which increased triglyceride levels were significantly associated with higher thrombosis risk (β = 3.38, 95% CI: 1.10-10.41, p = 0.03). This relationship was not apparent above 1.48 mmol/L (β = 0.49, 95% CI: 0.16–1.58, p = 0.23). Stratified analyses confirmed this non-linear association across subgroups.

Conclusion

Serum triglyceride levels exhibited a significant non-linear association with venous thrombosis risk in older Chinese fracture patients. Patients with triglyceride levels below 1.48 mmol/L may represent a vulnerable subgroup with increased thrombosis risk, suggesting the potential utility of triglyceride measurements for refined risk stratification and personalized thrombosis prophylaxis.