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Background &amp; aims <p>Increasing data indicate that the concentration of high-density lipoprotein particles (HDL-p) may be a strong indicator of cardiovascular disease. This study aimed to carry out a meta-analysis to examine the link between subclasses of HDL-p and the hazard of mortality in individuals suffering from cardiovascular diseases (CVDs).</p> Methods <p>A rigorous systematic search was executed through Scopus, PubMed, and Web of Science up to April 2025.</p> Results <p>Seven unique cohort studies were deemed eligible for incorporation in this meta-analysis. The overall hazard was derived by applying a random effects model. The results indicated a negative association of total HDL-p (RR: 0.74, 95% CI: 0.69–0.78, <i>P</i> &lt; 0.001) and small HDL-p with all-cause mortality (RR: 0.69, 95% CI: 0.63–0.75, <i>P</i> &lt; 0.001) for each 5 µmol/l increment. Similarly, each 5 µmol/l large HDL-p was directly related to all-cause mortality (RR: 1.71, 95% CI: 1.14– 2.56; <i>P</i> = 0.009). Moreover, each 5 µmol/l increase in small HDL-p was linked to a 33% reduction in CVD mortality (RR: 0.67, 95% CI: 0.50–0.91; <i>P</i> = 0.01).</p> Conclusion <p>This study revealed that small and total HDL-p were negatively correlated with all-cause mortality, whereas latge HDL-p was positively related to mortality from all causes. Additionally, small HDL-p had an inverse relationship with CVD mortality in patients with CVD.</p>

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High-density lipoprotein particles are associated with the risk of mortality from all-causes and cardiovascular diseases (CVDs) in patients with CVD: a systematic review and meta-analysis study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月17日

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  • Elham Sharifi-Zahabi,
  • Nooshin Nasiri,
  • Fatemeh Hajizadeh-Sharafabad,
  • Sobhan Mohammadi,
  • Shaghayegh Shahbazi,
  • Nahid Salehi

摘要

Background & aims

Increasing data indicate that the concentration of high-density lipoprotein particles (HDL-p) may be a strong indicator of cardiovascular disease. This study aimed to carry out a meta-analysis to examine the link between subclasses of HDL-p and the hazard of mortality in individuals suffering from cardiovascular diseases (CVDs).

Methods

A rigorous systematic search was executed through Scopus, PubMed, and Web of Science up to April 2025.

Results

Seven unique cohort studies were deemed eligible for incorporation in this meta-analysis. The overall hazard was derived by applying a random effects model. The results indicated a negative association of total HDL-p (RR: 0.74, 95% CI: 0.69–0.78, P < 0.001) and small HDL-p with all-cause mortality (RR: 0.69, 95% CI: 0.63–0.75, P < 0.001) for each 5 µmol/l increment. Similarly, each 5 µmol/l large HDL-p was directly related to all-cause mortality (RR: 1.71, 95% CI: 1.14– 2.56; P = 0.009). Moreover, each 5 µmol/l increase in small HDL-p was linked to a 33% reduction in CVD mortality (RR: 0.67, 95% CI: 0.50–0.91; P = 0.01).

Conclusion

This study revealed that small and total HDL-p were negatively correlated with all-cause mortality, whereas latge HDL-p was positively related to mortality from all causes. Additionally, small HDL-p had an inverse relationship with CVD mortality in patients with CVD.