Scholarlink

Background <p><b>&amp; aims</b>: Esophageal cancer (EC) is a tumor type with high invasiveness and poor prognosis, attracting scientists’ attention to its pathogenesis and etiology. Given the limited evidence and conflicting findings regarding the association between EC risk and RBC fatty acids, we aimed to evaluate this association.</p> Methods <p>The study utilized gas chromatography to analyze RBC fatty acids in 158 EC patients and 224 controls. Multivariable conditional logistic regression and restricted cubic spline analysis were employed to assess the association between EC risk and RBC fatty acids, as well as to determine the odds ratio with a 95% confidence interval (OR, 95% CI) for this association.</p> Results <p>Higher levels of total n-3 polyunsaturated fatty acids (n-3 PUFA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 index were associated with lower odds of being an EC case [OR<sub>T3−T1</sub> = 0.22 (0.12–0.41), OR<sub>T3−T1</sub> = 0.29 (0.15–0.54), OR<sub>T3−T1</sub> = 0.49 (0.27–0.88), and OR<sub>T3−T1</sub> = 0.19 (0.09–0.35), respectively]. Total saturated fatty acids (SFA), particularly palmitic acid (C16:0), stearic acid (C18:0), and arachidonic acid (C20:4n-6) in high concentrations, were associated with higher odds of being an EC case [OR<sub>T1−T3</sub> = 2.02 (1.11–3.70), OR<sub>T1−T3</sub> = 2.10 (1.15–3.87), OR<sub>T1−T3</sub> = 2.82 (1.53–5.30), and OR<sub>T1−T3</sub> = 2.07 (1.12–3.86), respectively]. Total monounsaturated fatty acids (MUFA) and total trans fatty acids (TFA) showed no significant association with EC case status.</p> Conclusion <p>The different types of RBC fatty acids may significantly influence susceptibility to EC. Higher levels of total n-3 PUFA in RBC, specifically DHA and EPA, were associated with lower odds of being an EC case, while higher levels of C20:4n-6, C18:0, and C16:0 were associated with higher odds.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月20日

查看全文
  • Hongming Yin,
  • Yongjin Wang,
  • Yujia Chen,
  • Qayyum Shehzad,
  • Feng Xiao

摘要

Background

& aims: Esophageal cancer (EC) is a tumor type with high invasiveness and poor prognosis, attracting scientists’ attention to its pathogenesis and etiology. Given the limited evidence and conflicting findings regarding the association between EC risk and RBC fatty acids, we aimed to evaluate this association.

Methods

The study utilized gas chromatography to analyze RBC fatty acids in 158 EC patients and 224 controls. Multivariable conditional logistic regression and restricted cubic spline analysis were employed to assess the association between EC risk and RBC fatty acids, as well as to determine the odds ratio with a 95% confidence interval (OR, 95% CI) for this association.

Results

Higher levels of total n-3 polyunsaturated fatty acids (n-3 PUFA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 index were associated with lower odds of being an EC case [ORT3−T1 = 0.22 (0.12–0.41), ORT3−T1 = 0.29 (0.15–0.54), ORT3−T1 = 0.49 (0.27–0.88), and ORT3−T1 = 0.19 (0.09–0.35), respectively]. Total saturated fatty acids (SFA), particularly palmitic acid (C16:0), stearic acid (C18:0), and arachidonic acid (C20:4n-6) in high concentrations, were associated with higher odds of being an EC case [ORT1−T3 = 2.02 (1.11–3.70), ORT1−T3 = 2.10 (1.15–3.87), ORT1−T3 = 2.82 (1.53–5.30), and ORT1−T3 = 2.07 (1.12–3.86), respectively]. Total monounsaturated fatty acids (MUFA) and total trans fatty acids (TFA) showed no significant association with EC case status.

Conclusion

The different types of RBC fatty acids may significantly influence susceptibility to EC. Higher levels of total n-3 PUFA in RBC, specifically DHA and EPA, were associated with lower odds of being an EC case, while higher levels of C20:4n-6, C18:0, and C16:0 were associated with higher odds.