Scholarlink

<p>Advancements in genetic engineering and synthetic biology have markedly accelerated the development and application of chimeric antigen receptor T (CAR-T) cell therapy for cancer treatment. Despite substantial progress, the treatment of solid tumors remains challenging, with suboptimal clinical outcomes and significant unmet needs. To address these ongoing challenges, considerable efforts are being made to enhance the safety, efficacy, and overall applicability of CAR-T cells therapy. This review outlines the key tumor features that impede CAR-T efficacy, focusing on intrinsic tumor factors and the influence of the microenvironment. We then provide a comprehensive overview of the promising next-generation CAR-T designs and discuss the combinatorial approaches aimed at improving antigen recognition, functional adaptability, and antitumor response, thereby expanding the therapeutic impact of CAR-T cells in solid-tumor settings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Next-generation CAR-T cells design: leveraging tumor features for enhanced efficacy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月19日

查看全文
  • Yanna Lei,
  • Ning Liu,
  • Diyuan Qin,
  • Ming Liu,
  • Yongsheng Wang

摘要

Advancements in genetic engineering and synthetic biology have markedly accelerated the development and application of chimeric antigen receptor T (CAR-T) cell therapy for cancer treatment. Despite substantial progress, the treatment of solid tumors remains challenging, with suboptimal clinical outcomes and significant unmet needs. To address these ongoing challenges, considerable efforts are being made to enhance the safety, efficacy, and overall applicability of CAR-T cells therapy. This review outlines the key tumor features that impede CAR-T efficacy, focusing on intrinsic tumor factors and the influence of the microenvironment. We then provide a comprehensive overview of the promising next-generation CAR-T designs and discuss the combinatorial approaches aimed at improving antigen recognition, functional adaptability, and antitumor response, thereby expanding the therapeutic impact of CAR-T cells in solid-tumor settings.