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<p>We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-<i>Cryptococcus</i> CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against <i>Cryptococcus</i>.</p>

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Persistent NK cell deficiency associated with pulmonary cryptococcosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月18日

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  • Martin Martinot,
  • Shu Shun Li,
  • Catherine Farnarier,
  • Cléa Dubrou,
  • Christelle Piperoglou,
  • Christopher H. Mody,
  • Frederic Vely

摘要

We describe pulmonary cryptococcosis in a 28-year-old previously healthy man. Exhaustive immunological investigations revealed a primary NK cell deficiency associated with a secondary impaired anti-Cryptococcus CD8 lymphocyte response and the expansion of a CD8Vβ14 + T cell clone. This case illustrates the potential role of NK cells in immunity against Cryptococcus.