Scholarlink

Background <p>While several studies have found positive associations between exposure to oil spill cleanup-related chemicals and hypertension, no study has examined these associations longitudinally.</p> Objective <p>This study examined associations of oil spill-related benzene, toluene, ethylbenzene, xylene, and n-hexane (BTEX-H) exposures, individually and as both the aggregate sum (total) of BTEX-H and the BTEX-H <i>mixture</i> with incident hypertension among Gulf Long-term Follow-up (GuLF) Study participants.</p> Methods <p>Participants were 18,619 <i>Deepwater Horizon (DWH)</i> oil spill cleanup and response workers who enrolled in the GuLF Study (2011–2013). Cumulative exposures to each BTEX-H chemical were estimated with a job-exposure matrix linking detailed self-reported <i>DWH</i> participant work histories to exposure group estimates developed from air monitoring data. We defined incident hypertension as the first self-reported physician diagnosis of hypertension or high blood pressure after each worker’s last date of cleanup work, as reported at enrollment or a follow-up interview (2013–2016 or 2017–2021). We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI). We used quantile g-computation to estimate the joint effect of the BTEX-H <i>mixture</i>.</p> Results <p>Approximately 20% (<i>n</i> = 3,779) of workers reported an incident hypertension diagnosis. Exposures to the individual BTEX-H chemicals were highly correlated (<i>r</i> = 0.87–0.95). The HRs comparing the highest to lowest quartiles of individual BTEX-H and total BTEX-H exposures ranged from 1.27 to 1.35. We found evidence of exposure-response trends across increasing quartiles of exposure. Each one quartile increase in the BTEX-H <i>mixture</i> was positively associated with incident hypertension (HR: 1.10, 95% CI: 1.07, 1.14).</p> Discussion <p>Oil spill cleanup work-related BTEX-H exposures were associated with the risk of incident hypertension, extending prior findings of cross-sectional associations. Since BTEX-H exposures are common in occupational and population settings, these findings may have broader public health implications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association of oil spill cleanup-related hydrocarbon exposure with incident hypertension up to 11 years after exposure in the Gulf Long-term Follow-up Study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月30日

查看全文
  • Opal P. Patel,
  • Jessie K. Edwards,
  • Anna M. Kucharska-Newton,
  • Eric A. Whitsel,
  • Kate E. Christenbury,
  • W. Braxton Jackson II,
  • Kaitlyn G. Lawrence,
  • Patricia A. Stewart,
  • Mark R. Stenzel,
  • Lawrence S. Engel,
  • Dale P. Sandler

摘要

Background

While several studies have found positive associations between exposure to oil spill cleanup-related chemicals and hypertension, no study has examined these associations longitudinally.

Objective

This study examined associations of oil spill-related benzene, toluene, ethylbenzene, xylene, and n-hexane (BTEX-H) exposures, individually and as both the aggregate sum (total) of BTEX-H and the BTEX-H mixture with incident hypertension among Gulf Long-term Follow-up (GuLF) Study participants.

Methods

Participants were 18,619 Deepwater Horizon (DWH) oil spill cleanup and response workers who enrolled in the GuLF Study (2011–2013). Cumulative exposures to each BTEX-H chemical were estimated with a job-exposure matrix linking detailed self-reported DWH participant work histories to exposure group estimates developed from air monitoring data. We defined incident hypertension as the first self-reported physician diagnosis of hypertension or high blood pressure after each worker’s last date of cleanup work, as reported at enrollment or a follow-up interview (2013–2016 or 2017–2021). We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI). We used quantile g-computation to estimate the joint effect of the BTEX-H mixture.

Results

Approximately 20% (n = 3,779) of workers reported an incident hypertension diagnosis. Exposures to the individual BTEX-H chemicals were highly correlated (r = 0.87–0.95). The HRs comparing the highest to lowest quartiles of individual BTEX-H and total BTEX-H exposures ranged from 1.27 to 1.35. We found evidence of exposure-response trends across increasing quartiles of exposure. Each one quartile increase in the BTEX-H mixture was positively associated with incident hypertension (HR: 1.10, 95% CI: 1.07, 1.14).

Discussion

Oil spill cleanup work-related BTEX-H exposures were associated with the risk of incident hypertension, extending prior findings of cross-sectional associations. Since BTEX-H exposures are common in occupational and population settings, these findings may have broader public health implications.