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Background <p>The evidence linking dietary indices to Parkinson’s disease (PD) risk remains limited. This study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and PD risk in middle-aged and elderly populations.</p> Methods <p>Cross-sectional data were obtained from the 2007–2020 cycles of the National Health and Nutrition Examination Survey (NHANES), including 17,373 participants aged 40 years or older. PD was defined by antiparkinsonian medication use. DI-GM scores were calculated based on 14 dietary components. Multiple logistic regression and a restricted cubic spline model (RCS) were used to test the relationship between DI-GM and PD. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the results.</p> Results <p>Among 17,373 participants, those with PD (<i>n</i> = 232) had lower DI-GM scores compared to non-PD individuals. Higher DI-GM scores (≥ 6) were associated with a 49% reduction in PD prevalence. RCS analysis showed a non-linear relationship between DI-GM and PD (<i>P</i> &lt; 0.05). Subgroup and sensitivity analyses confirmed stable associations across demographic groups and after adjusting for comorbidities.</p> Conclusions <p>A gut microbiota-friendly diet, as measured by DI-GM, is associated with reduced PD risk, especially in the higher DI-GM score. This finding may inform future dietary guidelines for the prevention of PD.</p>

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Cross-sectional analyses between the dietary index for gut microbiota and Parkinson’s disease in the middle-aged and elderly population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月30日

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  • Yiming Zhan,
  • Yuhang Liu,
  • Huxingzi Liu,
  • Siyao Gao,
  • Jialing Tang

摘要

Background

The evidence linking dietary indices to Parkinson’s disease (PD) risk remains limited. This study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and PD risk in middle-aged and elderly populations.

Methods

Cross-sectional data were obtained from the 2007–2020 cycles of the National Health and Nutrition Examination Survey (NHANES), including 17,373 participants aged 40 years or older. PD was defined by antiparkinsonian medication use. DI-GM scores were calculated based on 14 dietary components. Multiple logistic regression and a restricted cubic spline model (RCS) were used to test the relationship between DI-GM and PD. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the results.

Results

Among 17,373 participants, those with PD (n = 232) had lower DI-GM scores compared to non-PD individuals. Higher DI-GM scores (≥ 6) were associated with a 49% reduction in PD prevalence. RCS analysis showed a non-linear relationship between DI-GM and PD (P < 0.05). Subgroup and sensitivity analyses confirmed stable associations across demographic groups and after adjusting for comorbidities.

Conclusions

A gut microbiota-friendly diet, as measured by DI-GM, is associated with reduced PD risk, especially in the higher DI-GM score. This finding may inform future dietary guidelines for the prevention of PD.