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<p><i>Plasmodium falciparum</i> is the leading cause of severe malaria. The spleen plays a central role in the clearance of the infection in conjunction with antimalarial treatment. Splenectomized patients lack sufficient clearance functions. We report a case of severe <i>P. falciparum</i> infection with multi-organ involvement acquired in Uganda in a splenectomized patient with a persistently high parasitemia level despite appropriate antimalarial treatment. The case emphasizes the challenges associated with severe malaria in asplenic patients.</p>

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Severe Plasmodium falciparum infection with multi-organ involvement in an asplenic patient: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月3日

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  • Bolette Wittenberg,
  • Gitte Nyvang Hartmeyer,
  • David Fuglsang-Damgaard,
  • Torsten Roed,
  • Helle Hansson,
  • Fredrikke Christie Knudtzen

摘要

Plasmodium falciparum is the leading cause of severe malaria. The spleen plays a central role in the clearance of the infection in conjunction with antimalarial treatment. Splenectomized patients lack sufficient clearance functions. We report a case of severe P. falciparum infection with multi-organ involvement acquired in Uganda in a splenectomized patient with a persistently high parasitemia level despite appropriate antimalarial treatment. The case emphasizes the challenges associated with severe malaria in asplenic patients.