Background <p>Malaria is continuously a great health challenge in Ethiopia, which is worst during armed conflict. Hence, continuous malaria prevention practice is very essential. However, there is no evidence of malaria prevention practices among the residents in Ethiopia during armed conflict. Thus, this study aimed to provide tangible evidence regarding malaria prevention practices and associated factors among residents in Fogera district, Ethiopia, during the armed conflict between Amhara Fano and the federal government, 2025.</p> Method <p>A community-based cross-sectional study was conducted among residents in Fogera district from September 1–30, 2025. Multistage sampling was applied to select households. The data was collected by trained nurses via face-to-face interview and analyzed using SPSS version 25. Data were summarized with frequency, percentage, mean and standard deviation for both continuous and categorical variables. All predictors with a p-value of less than 0.25 in bi-variable analysis were entered in to multivariable logistic regression to control the confounding effect. An AOR with 95% CI and a p-value of &lt; 0.05 was used to announce statistically significant.</p> Result <p>A total of 804 participants were included with a 99.5% response rate. 48% of respondents had good practice of malaria prevention and control interventions. Predictors including male gender (AOR = 1.41, 95% CI 1.10–1.81), urban residence (AOR = 1.50, 95% CI 1.01–5.92), having bed net (AOR = 6.91, 95% CI 3.79–8.59) and adequate knowledge (AOR = 2.32, 95% CI 1.34–4.03) were significantly associated with malaria prevention practice.</p> Conclusion <p>Almost half of the residents had poor practice of malaria prevention and control methods and one-third of the participants had no bed net. Hence, health officials and partners need to give more attention by providing ongoing supervision, support and access to a bed net.</p>