Scholarlink

<p>TAGLN is identified as a key prognostic gene in colorectal cancer through TCGA-COAD analysis, with high expression correlating with poor survival and advanced tumor stage. Functionally, TAGLN overexpression promotes epithelial-mesenchymal transition and enhances cancer cell migration. Transcriptomic profiling reveals its involvement in extracellular matrix remodeling and cell adhesion pathways. Mechanistically, TAGLN expression is upregulated by stiff tumor-mimicking extracellular matrix and is correlated with key mediators of collagen crosslinking and EMT. Clinically, TAGLN exhibits progressive overexpression from normal epithelium to primary tumors and metastatic lesions. These findings establish TAGLN as a stiffness-responsive regulator of ECM remodeling and EMT, driving colorectal cancer metastasis and serving as a potential therapeutic target.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

TAGLN: a stiffness-driven prognostic biomarker for metastatic colorectal cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月30日

查看全文
  • Yanshuo Ye,
  • Yiyang Jia,
  • Wei Li

摘要

TAGLN is identified as a key prognostic gene in colorectal cancer through TCGA-COAD analysis, with high expression correlating with poor survival and advanced tumor stage. Functionally, TAGLN overexpression promotes epithelial-mesenchymal transition and enhances cancer cell migration. Transcriptomic profiling reveals its involvement in extracellular matrix remodeling and cell adhesion pathways. Mechanistically, TAGLN expression is upregulated by stiff tumor-mimicking extracellular matrix and is correlated with key mediators of collagen crosslinking and EMT. Clinically, TAGLN exhibits progressive overexpression from normal epithelium to primary tumors and metastatic lesions. These findings establish TAGLN as a stiffness-responsive regulator of ECM remodeling and EMT, driving colorectal cancer metastasis and serving as a potential therapeutic target.