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<p>Even though the paper entitled: The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells” provides informative details regarding viral contribution in cancer biology, its classification of Herpes Simplex Virus (HSV) and Varicella-Zoster Virus (VZV) as oncoviruses is inaccurate.</p><p>Current evidence demonstrates that while HSV and VZV may reactivate in immunocompromised cancer patients, there is no causative relationship between these two viruses and oncogenesis. It is necessary to make a distinction between cancer-inducing viruses and reactivated viruses due to immune suppression among cancer patients.</p>

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Oncovirus classification and insights into herpes simplex virus, Varicella-Zoster virus

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月3日

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  • Amir Ghaemi,
  • Sanaz Sadeh

摘要

Even though the paper entitled: The role of oncolytic virotherapy and viral oncogenes in the cancer stem cells: a review of virus in cancer stem cells” provides informative details regarding viral contribution in cancer biology, its classification of Herpes Simplex Virus (HSV) and Varicella-Zoster Virus (VZV) as oncoviruses is inaccurate.

Current evidence demonstrates that while HSV and VZV may reactivate in immunocompromised cancer patients, there is no causative relationship between these two viruses and oncogenesis. It is necessary to make a distinction between cancer-inducing viruses and reactivated viruses due to immune suppression among cancer patients.