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Background <p>A variety of probiotics have been utilized as chassis strains and engineered to develop the synthetic probiotics for disease treatment. Among these probiotics, <i>Lactobacilli</i>, which are generally viewed as safe and capable of colonizing the gastrointestinal tract effectively, are widely used.</p> Main body of abstract <p>We review recent advancements in the engineering of <i>Lactobacilli</i> for disease treatment. Specifically, the <i>Lactobacilli</i> that are used for the construction of synthetic probiotics, the application of these engineered strains for diseases treatment, and the therapeutic outcomes of these engineered microbes are summarized in this review. Moreover, the applications of these engineered strains for disease treatment are categorized based on their engineering strategies. Of note, we compare the advantages and disadvantages of various engineering strategies and offer insights for the future development of genetically modified <i>Lactobacillus</i> strains with stable and safe properties.</p> Short conclusion <p>Our study comprehensively reviews researches on engineering diverse <i>Lactobacillus</i> strains for disease treatment, categorized by their engineering strategies, and emphasizes the importance of developing synthetic probiotics with stable and safe characteristics to enhance their therapeutic applications.</p>

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Metabolic engineering of Lactobacilli spp. for disease treatment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月6日

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  • Yunpeng Yang,
  • Peijun Yu,
  • Yufei Huang,
  • Wanying Zhang,
  • Yanhong Nie,
  • Changshan Gao

摘要

Background

A variety of probiotics have been utilized as chassis strains and engineered to develop the synthetic probiotics for disease treatment. Among these probiotics, Lactobacilli, which are generally viewed as safe and capable of colonizing the gastrointestinal tract effectively, are widely used.

Main body of abstract

We review recent advancements in the engineering of Lactobacilli for disease treatment. Specifically, the Lactobacilli that are used for the construction of synthetic probiotics, the application of these engineered strains for diseases treatment, and the therapeutic outcomes of these engineered microbes are summarized in this review. Moreover, the applications of these engineered strains for disease treatment are categorized based on their engineering strategies. Of note, we compare the advantages and disadvantages of various engineering strategies and offer insights for the future development of genetically modified Lactobacillus strains with stable and safe properties.

Short conclusion

Our study comprehensively reviews researches on engineering diverse Lactobacillus strains for disease treatment, categorized by their engineering strategies, and emphasizes the importance of developing synthetic probiotics with stable and safe characteristics to enhance their therapeutic applications.