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Background <p>Rheumatoid arthritis-associated autoantibodies have been associated with interstitial lung abnormalities (ILA) among community-dwelling adults. We aimed to determine whether greater numbers of positive anti-citrullinated protein antibodies (ACPAs) are associated with ILA in community-dwelling adults.</p> Methods <p>We performed a period cross-sectional study. We measured 29 ACPAs via Bio-Plex bead array (2003–2005) and ILA on full-lung CTs (2010–2012) in 868 participants enrolled in the Multi-Ethnic Study of Atherosclerosis. A positive ACPA was defined as titer &gt; 75th percentile. We used generalized additive and logistic regression models to examine associations between number of positive ACPA and ILA and tested for effect modification by race/ethnicity.</p> Results <p>In an adjusted model, each 1 unit increase in log-transformed number of positive ACPA was associated with a 17% decrease in odds of ILA (OR 0.83, 95% CI 0.68–1.01). Race/ethnicity modified the association between log-transformed number of positive ACPA and ILA (interaction p-value 0.03), such that each 1 unit increase in log-transformed number of positive ACPA was associated with a 39% decrease in the adjusted odds of ILA among African American participants (OR 0.61, 95% CI 0.37–0.99) and a 42% decrease in the adjusted odds of ILA among Hispanic participants (OR 0.58, 95% CI 0.36–0.91). There was no significant association between log-transformed number of positive ACPA and ILA among White or Chinese American participants.</p> Conclusions <p>In this large population-based multi-ethnic study, an expanded ACPA repertoire was associated with a lower burden of ILA on CT, especially among African American and Hispanic participants.</p>

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Association between anti-citrullinated peptide antibodies and subclinical interstitial lung disease in community-dwelling adults: the multi-ethnic study of atherosclerosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月13日

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  • Jenna V. Lanz,
  • Jan Hughes-Austin,
  • Anna J. Podolanczuk,
  • John S. Kim,
  • Mary M. Salvatore,
  • William H. Robinson,
  • Ganesh Raghu,
  • Eric A. Hoffman,
  • John D. Newell Jr,
  • Jubal R. Watts Jr,
  • P. Hrudaya Nath,
  • Sushilkumar K. Sonavane,
  • Jon T. Giles,
  • Christine Kim Garcia,
  • R. Graham Barr,
  • Elana J. Bernstein

摘要

Background

Rheumatoid arthritis-associated autoantibodies have been associated with interstitial lung abnormalities (ILA) among community-dwelling adults. We aimed to determine whether greater numbers of positive anti-citrullinated protein antibodies (ACPAs) are associated with ILA in community-dwelling adults.

Methods

We performed a period cross-sectional study. We measured 29 ACPAs via Bio-Plex bead array (2003–2005) and ILA on full-lung CTs (2010–2012) in 868 participants enrolled in the Multi-Ethnic Study of Atherosclerosis. A positive ACPA was defined as titer > 75th percentile. We used generalized additive and logistic regression models to examine associations between number of positive ACPA and ILA and tested for effect modification by race/ethnicity.

Results

In an adjusted model, each 1 unit increase in log-transformed number of positive ACPA was associated with a 17% decrease in odds of ILA (OR 0.83, 95% CI 0.68–1.01). Race/ethnicity modified the association between log-transformed number of positive ACPA and ILA (interaction p-value 0.03), such that each 1 unit increase in log-transformed number of positive ACPA was associated with a 39% decrease in the adjusted odds of ILA among African American participants (OR 0.61, 95% CI 0.37–0.99) and a 42% decrease in the adjusted odds of ILA among Hispanic participants (OR 0.58, 95% CI 0.36–0.91). There was no significant association between log-transformed number of positive ACPA and ILA among White or Chinese American participants.

Conclusions

In this large population-based multi-ethnic study, an expanded ACPA repertoire was associated with a lower burden of ILA on CT, especially among African American and Hispanic participants.