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Background <p>Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders during pregnancy and has been associated with recurrent pregnancy loss (RPL) and other obstetric complications. The Factor V Leiden (FVL) is a common inherited thrombophilic mutation. However, data on the prevalence of the FVL mutation among Yemeni women with GDM and a history of RPL remain scarce. Therefore, this case–control study aimed to determine the prevalence of the FVL mutation and examine its association among Yemeni women with GDM and recurrent pregnancy loss compared with healthy pregnant controls.</p> Methods <p>This case–control study included 200 Yemeni women with GDM and 200 healthy pregnant controls without a previous history of GDM. Ethical approval was obtained from the Research Ethics Committee of the Faculty of Medicine and Health Sciences, Sana’a University. The GDM group consisted of women with a history of adverse pregnancy outcomes, including spontaneous abortion and/or stillbirth. The FVL (G1691A) mutation was detected by real-time PCR using genomic DNA extracted from peripheral blood leukocytes (white blood cells). Statistical analyses were performed using SPSS version 22.</p> Results <p>Allelic frequencies for FVL were 0.93 (G) and 0.07 (A) in the GDM group, compared to 0.98 (G) and 0.02 (A) in controls. The FVL mutation was more common among women with GDM and recurrent pregnancy loss. Clinical findings in the GDM group showed significantly higher PT, APTT, fasting blood glucose, blood pressure, HbA1c, and lipid profile values than healthy controls. Differences in FVL mutation incidence and clinical measures between the GDM and control groups were statistically significant.</p> Conclusion <p>Our study found a higher prevalence of the Factor V Leiden (FVL) mutation among Yemeni women with gestational diabetes mellitus (GDM) and a history of recurrent pregnancy loss (RPL) than among healthy pregnant controls. The observed association suggests that the FVL mutation may contribute to the clinical profile of this group. However, further large-scale prospective studies with appropriate comparison groups are needed to validate these findings and to clarify whether FVL screening could have a meaningful role in the clinical management of pregnancies.</p>

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Prevalence of Factor V Leiden mutation in yemeni women with gestational diabetes mellitus and recurrent pregnancy loss: a case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月31日

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  • Nabeela A. Al Matari,
  • Abdulkarim M. Al-Obeidi,
  • Ebtesam Al-Zabedi

摘要

Background

Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders during pregnancy and has been associated with recurrent pregnancy loss (RPL) and other obstetric complications. The Factor V Leiden (FVL) is a common inherited thrombophilic mutation. However, data on the prevalence of the FVL mutation among Yemeni women with GDM and a history of RPL remain scarce. Therefore, this case–control study aimed to determine the prevalence of the FVL mutation and examine its association among Yemeni women with GDM and recurrent pregnancy loss compared with healthy pregnant controls.

Methods

This case–control study included 200 Yemeni women with GDM and 200 healthy pregnant controls without a previous history of GDM. Ethical approval was obtained from the Research Ethics Committee of the Faculty of Medicine and Health Sciences, Sana’a University. The GDM group consisted of women with a history of adverse pregnancy outcomes, including spontaneous abortion and/or stillbirth. The FVL (G1691A) mutation was detected by real-time PCR using genomic DNA extracted from peripheral blood leukocytes (white blood cells). Statistical analyses were performed using SPSS version 22.

Results

Allelic frequencies for FVL were 0.93 (G) and 0.07 (A) in the GDM group, compared to 0.98 (G) and 0.02 (A) in controls. The FVL mutation was more common among women with GDM and recurrent pregnancy loss. Clinical findings in the GDM group showed significantly higher PT, APTT, fasting blood glucose, blood pressure, HbA1c, and lipid profile values than healthy controls. Differences in FVL mutation incidence and clinical measures between the GDM and control groups were statistically significant.

Conclusion

Our study found a higher prevalence of the Factor V Leiden (FVL) mutation among Yemeni women with gestational diabetes mellitus (GDM) and a history of recurrent pregnancy loss (RPL) than among healthy pregnant controls. The observed association suggests that the FVL mutation may contribute to the clinical profile of this group. However, further large-scale prospective studies with appropriate comparison groups are needed to validate these findings and to clarify whether FVL screening could have a meaningful role in the clinical management of pregnancies.