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Background <p>Recently, the association of IGFBP-3 polymorphism and cancer risk has attracted many attentions. Previous studies have shown that IGFBP-3 rs2854744 was associated with cancer, but the results were conflicting.</p> Method and results <p>We performed a meta-analysis including 33 studies with 24,688 cases and 28,972 controls to seek the association among them. A significant increase of cancer risk was found between the IGFBP-3 rs2854744 Polymorphism and cancer risk in Recessive Model (CC vs. AC/AA: OR = 1.097, 95%CI: 1.020, 1.180, <i>P</i> &lt; 0.05). While in subgroup analysis, A same increase of breast cancer risk also have been shown in our study in Recessive Model (CC vs. AC/AA: OR = 1.126, 95%CI: 1.007, 1.260, <i>P</i> &lt; 0.05).</p> Conclusions <p>The results of our meta-analysis concluded that the IGFBP-3 rs2854744 polymorphism was closely related with the increase of cancer risk while further large size case–control studies are required.</p>

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Association between the IGFBP-3 rs2854744 polymorphism and cancer risk: a meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月10日

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  • Dan Sun,
  • Lihua Xu,
  • Yajuan Chen,
  • WanJu Wang,
  • Na Wang,
  • Gang Hu

摘要

Background

Recently, the association of IGFBP-3 polymorphism and cancer risk has attracted many attentions. Previous studies have shown that IGFBP-3 rs2854744 was associated with cancer, but the results were conflicting.

Method and results

We performed a meta-analysis including 33 studies with 24,688 cases and 28,972 controls to seek the association among them. A significant increase of cancer risk was found between the IGFBP-3 rs2854744 Polymorphism and cancer risk in Recessive Model (CC vs. AC/AA: OR = 1.097, 95%CI: 1.020, 1.180, P < 0.05). While in subgroup analysis, A same increase of breast cancer risk also have been shown in our study in Recessive Model (CC vs. AC/AA: OR = 1.126, 95%CI: 1.007, 1.260, P < 0.05).

Conclusions

The results of our meta-analysis concluded that the IGFBP-3 rs2854744 polymorphism was closely related with the increase of cancer risk while further large size case–control studies are required.