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<p>Rebound tonometers are widely used for intraocular pressure (IOP) monitoring in animal experiments. However, previous studies and clinical experience have demonstrated that their measurements are susceptible to operator-dependent factors, such as variations in measuring distance, probe angle, and corneal impact position, all of which may contribute to reading variability. To evaluate the measurement stability of the iFalcon<sup>TM</sup>V700 rebound tonometer under different measuring conditions, this study employed a stepwise pressure-increasing protocol to set eight target IOP levels (10–50 mmHg) in two enucleated rabbit eyes (<i>n</i> = 2). We systematically investigated the effects of measuring distance (4–7&#xa0;mm), measuring angle (approximately 30° superior, inferior, left, and right relative to the corneal normal), and corneal measuring location (central cornea and 3&#xa0;mm peripheral cornea) on IOP readings. Paired t-tests were used to compare measurements between each test condition and its corresponding reference condition. Stratified analyses were performed across different IOP levels to assess the potential influence of IOP. The results showed that the maximum mean differences caused by distance, angle, and position factors were − 1.8125 mmHg, − 0.9450 mmHg, and − 1.8175 mmHg, respectively, all of which were less than 2 mmHg, with low measurement dispersion at each IOP gradient. Although the iFalcon<sup>TM</sup>V700 exhibited statistically significant dependent biases under the aforementioned operating conditions, the absolute magnitudes were limited and had little impact on experimental interpretation and conclusions, suggesting that the device demonstrates reasonable measurement stability under the tested conditions.</p>

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Sensitivity of the iFalconTMV700 rebound tonometer to measurement distance, angle and position in ex-vivo rabbit eyes

  • 期刊论文

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  • 发表日期：

    2026年7月20日

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  • Jing Jin,
  • Hao Cheng,
  • Yunhao Su,
  • Ji Fu

摘要

Rebound tonometers are widely used for intraocular pressure (IOP) monitoring in animal experiments. However, previous studies and clinical experience have demonstrated that their measurements are susceptible to operator-dependent factors, such as variations in measuring distance, probe angle, and corneal impact position, all of which may contribute to reading variability. To evaluate the measurement stability of the iFalconTMV700 rebound tonometer under different measuring conditions, this study employed a stepwise pressure-increasing protocol to set eight target IOP levels (10–50 mmHg) in two enucleated rabbit eyes (n = 2). We systematically investigated the effects of measuring distance (4–7 mm), measuring angle (approximately 30° superior, inferior, left, and right relative to the corneal normal), and corneal measuring location (central cornea and 3 mm peripheral cornea) on IOP readings. Paired t-tests were used to compare measurements between each test condition and its corresponding reference condition. Stratified analyses were performed across different IOP levels to assess the potential influence of IOP. The results showed that the maximum mean differences caused by distance, angle, and position factors were − 1.8125 mmHg, − 0.9450 mmHg, and − 1.8175 mmHg, respectively, all of which were less than 2 mmHg, with low measurement dispersion at each IOP gradient. Although the iFalconTMV700 exhibited statistically significant dependent biases under the aforementioned operating conditions, the absolute magnitudes were limited and had little impact on experimental interpretation and conclusions, suggesting that the device demonstrates reasonable measurement stability under the tested conditions.