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Background <p>Synbiotic products are those Functional foods/feeds that contain both probiotic and prebiotic strains and have health-promoting effects beyond probiotics or prebiotics alone. This study aimed to investigate the effect of synbiotic feed containing the probiotic strain <i>Lactobacillus acidophilus</i> La5 (10<sup>12</sup>&#xa0;cfu/g) and inulin (5%) on changes in Thyroid hormones (T3, T4), TSH, LH, FSH, and Testosterone in male dogs throughout 24&#xa0;days.</p> Materials and methods <p>In addition to the basic feed, the dogs in the treatment group also received the synbiotic supplement at 5% in each of their three meals during 24&#xa0;days. Then, the serum levels of LH, FSH, TSH, and Testosterone were measured with an ELISA kit and finally, the obtained data were statistically analyzed.</p> Results <p>The results showed that the consumption of this formulated synbiotic feed had no negative effect on the profile of Thyroid hormones (T3: from 1.09 ± 0.51 to 0.95 ± 0.40&#xa0;ng/ml [<i>p</i> &gt; <i>0.05</i>]; and T4: from 6.60 ± 4.33 to 4.70 ± 4.29&#xa0;µg/dl [<i>p</i> &gt; <i>0.05</i>]) as well as TSH (from 0.07 ± 0.09 to 0.03 ± 0.00 mIU/L [<i>p</i> &gt; <i>0.05</i>]), Testosterone (from 1.56 ± 0.66 to 1.26 ± 0.93&#xa0;ng/ml [<i>p</i> &gt; <i>0.05</i>]), FSH (from 4.72 ± 1.12 to 11.55 ± 3.42 mIU/ml [<i>p</i> = <i>0.008</i>]), LH (from 0.56 ± 0.48 to 0.31 ± 0.15 mIU/ml [<i>p</i> &gt; <i>0.05</i>]), and the changes in the amounts of these hormones was in the normal range during 24&#xa0;days.</p> Conclusion <p>It concluded that the consumption of synbiotic feed (<i>L. acidophilus</i> + inulin, at the rate of 5%) in male dogs has no significant adverse effects were observed within the study period on Thyroid, TSH, and sex hormones and it seems that it may be used for a long time to take health-promoting effects without harming hormonal activities.</p>

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Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi Dogs

  • 期刊论文

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  • 发表日期：

    2025年5月2日

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  • Ali Khatami,
  • Hadi Pourjafar,
  • Mehrdad Neshat Gharamaleki

摘要

Background

Synbiotic products are those Functional foods/feeds that contain both probiotic and prebiotic strains and have health-promoting effects beyond probiotics or prebiotics alone. This study aimed to investigate the effect of synbiotic feed containing the probiotic strain Lactobacillus acidophilus La5 (1012 cfu/g) and inulin (5%) on changes in Thyroid hormones (T3, T4), TSH, LH, FSH, and Testosterone in male dogs throughout 24 days.

Materials and methods

In addition to the basic feed, the dogs in the treatment group also received the synbiotic supplement at 5% in each of their three meals during 24 days. Then, the serum levels of LH, FSH, TSH, and Testosterone were measured with an ELISA kit and finally, the obtained data were statistically analyzed.

Results

The results showed that the consumption of this formulated synbiotic feed had no negative effect on the profile of Thyroid hormones (T3: from 1.09 ± 0.51 to 0.95 ± 0.40 ng/ml [p > 0.05]; and T4: from 6.60 ± 4.33 to 4.70 ± 4.29 µg/dl [p > 0.05]) as well as TSH (from 0.07 ± 0.09 to 0.03 ± 0.00 mIU/L [p > 0.05]), Testosterone (from 1.56 ± 0.66 to 1.26 ± 0.93 ng/ml [p > 0.05]), FSH (from 4.72 ± 1.12 to 11.55 ± 3.42 mIU/ml [p = 0.008]), LH (from 0.56 ± 0.48 to 0.31 ± 0.15 mIU/ml [p > 0.05]), and the changes in the amounts of these hormones was in the normal range during 24 days.

Conclusion

It concluded that the consumption of synbiotic feed (L. acidophilus + inulin, at the rate of 5%) in male dogs has no significant adverse effects were observed within the study period on Thyroid, TSH, and sex hormones and it seems that it may be used for a long time to take health-promoting effects without harming hormonal activities.