Scholarlink

Background <p>Adolescence is a sensitive period of brain development when perceived stress can shape emotional and cognitive outcomes. However, it remains unclear how neural vulnerability modulates these effects.</p> Methods <p>In a longitudinal cohort of 407 adolescents, we assessed perceived stress, emotional symptoms, and cognitive function at baseline and follow-up. Neural vulnerability was indexed using polyconnectomic scoring for major depressive disorder (PCS-MDD), derived from large-scale functional connectivity patterns. An independent cohort of 80 adolescents with clinically diagnosed depressive disorders was included to explore the generalizability of the findings.</p> Results <p>At baseline, perceived stress was strongly associated with anxiety (<i>β</i> = 0.59, <i>p</i> &lt; 0.001) and depressive symptoms (<i>β</i> = 0.55, <i>p</i> &lt; 0.001), and was modestly associated with lower performance across multiple cognitive domains. Longitudinally, increases in perceived stress were robustly associated with increases in anxiety (<i>β</i> = 0.56, <i>p</i> &lt; 0.001) and depressive symptoms (<i>β</i> = 0.52, <i>p</i> &lt; 0.001). Moreover, PCS-MDD significantly moderated these associations (anxiety symptoms: <i>p</i> = 0.025, <i>ΔR</i><sup><i>2</i></sup> = 0.008; depressive symptoms: <i>p</i> &lt; 0.001, <i>ΔR</i><sup>2</sup> = 0.023). Additionally, baseline PCS-MDD was significantly associated with follow-up anxiety (<i>β</i> = 0.13, <i>p</i> = 0.024) and depressive symptoms (<i>β</i> = 0.11, <i>p</i> = 0.043). Exploratory analyses further indicated that perceived stress was most strongly associated with depressive symptoms among adolescents with clinically diagnosed depressive disorders and higher PCS-MDD.</p> Conclusions <p>Higher PCS-MDD is associated with greater variability in stress-related emotional outcomes during adolescence. These results suggest that neural vulnerability may moderate the emotional correlates of stress and underscore the potential relevance of personalized interventions targeting stress regulation in youth with elevated vulnerability profiles.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月24日

查看全文
  • Yuan Liu,
  • Meijuan Li,
  • Chengfeng Chen,
  • Shiying Wang,
  • Ying Gao,
  • Yifan Jing,
  • Yan Zhou,
  • Mengxin Xie,
  • Changlin Zhang,
  • Zhongchun Liu,
  • Bin Zhang,
  • Jie Li

摘要

Background

Adolescence is a sensitive period of brain development when perceived stress can shape emotional and cognitive outcomes. However, it remains unclear how neural vulnerability modulates these effects.

Methods

In a longitudinal cohort of 407 adolescents, we assessed perceived stress, emotional symptoms, and cognitive function at baseline and follow-up. Neural vulnerability was indexed using polyconnectomic scoring for major depressive disorder (PCS-MDD), derived from large-scale functional connectivity patterns. An independent cohort of 80 adolescents with clinically diagnosed depressive disorders was included to explore the generalizability of the findings.

Results

At baseline, perceived stress was strongly associated with anxiety (β = 0.59, p < 0.001) and depressive symptoms (β = 0.55, p < 0.001), and was modestly associated with lower performance across multiple cognitive domains. Longitudinally, increases in perceived stress were robustly associated with increases in anxiety (β = 0.56, p < 0.001) and depressive symptoms (β = 0.52, p < 0.001). Moreover, PCS-MDD significantly moderated these associations (anxiety symptoms: p = 0.025, ΔR2 = 0.008; depressive symptoms: p < 0.001, ΔR2 = 0.023). Additionally, baseline PCS-MDD was significantly associated with follow-up anxiety (β = 0.13, p = 0.024) and depressive symptoms (β = 0.11, p = 0.043). Exploratory analyses further indicated that perceived stress was most strongly associated with depressive symptoms among adolescents with clinically diagnosed depressive disorders and higher PCS-MDD.

Conclusions

Higher PCS-MDD is associated with greater variability in stress-related emotional outcomes during adolescence. These results suggest that neural vulnerability may moderate the emotional correlates of stress and underscore the potential relevance of personalized interventions targeting stress regulation in youth with elevated vulnerability profiles.