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Background <p>Pneumococcal vaccination reduces morbidity and mortality among older adults, yet coverage remains suboptimal in China. This study aimed to assess the effectiveness of a pay-it-forward intervention (covering two-thirds of the pneumococcal vaccination cost and offering the option to donate) in increasing pneumococcal vaccination among older adults (aged 60&#xa0;years or older) in China, compared to standard-of-care self-paid vaccination.</p> Methods <p>We used block randomization (block size = 4) to assign participants to a pay-it-forward arm and a standard-of-care arm in a 1:1 ratio. The primary outcome was pneumococcal vaccination. Secondary outcomes included influenza vaccine uptake, vaccine confidence, successful vaccine referral, and cost-effectiveness. Logistic regression analysis was used to compare PPSV-23 and influenza vaccination coverage and vaccine confidence between the two groups. The cost-effectiveness of the interventions was assessed using a micro-costing approach from the healthcare provider’s perspective.</p> Results <p>From January to September 2024, 221 older adults were randomized (110 in the pay-it-forward group and 111 in the standard-of-care group). Pneumococcal and influenza vaccine uptake were significantly higher in the pay-it-forward arm (70.9% and 30.0%) than in the standard-of-care arm (13.5% and 17.1%), with adjusted odds ratios of 17.20 (95% <i>CI</i>, 8.39–37.60) and 2.29 (95% <i>CI</i>, 1.17–4.65). The pay-it-forward group also exhibited greater confidence in the safety (4.29, 95% <i>CI</i>, 1.78–11.50), importance (5.15, 95% <i>CI</i>, 2.05–14.60), and effectiveness (7.14, 95% <i>CI,</i> 2.36–27.50) of the vaccine than that in the standard-of-care group. The pay-it-forward group had a higher successful vaccine referral rate (15.5% vs. 10.8%) and had a lower economic cost per person vaccinated (US $95.67 vs. US $278.56) compared with the standard-of-care arm.</p> Conclusions <p>Our findings demonstrate that the pay-it-forward intervention significantly enhances pneumococcal and influenza vaccination coverage and improves vaccine confidence among the older adults. This study highlights the potential of the pay-it-forward intervention as an effective means to boost health service utilization.</p> Trial registration <p>2024–01-03, Chinese Clinical Trial Registry, ChiCTR2400079410.</p>

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Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月19日

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  • Jiao Qin,
  • Chunxing Tao,
  • Ting Huang,
  • Liangjia Wei,
  • Jinfeng He,
  • Ruby Congjiang Wang,
  • Dan Wu,
  • Shiyu Qin,
  • Qiuqian Su,
  • Yanxiao Gao,
  • Shuiming Chen,
  • Ganqin Wang,
  • Zhifeng Lin,
  • Xinju Huang,
  • Xianyan Tang,
  • Chuanyi Ning,
  • Hao Liang,
  • Weiming Tang,
  • Salma Gayed,
  • Jason J Ong,
  • Junjun Jiang,
  • Li Ye,
  • Joseph D Tucker,
  • Bingyu Liang

摘要

Background

Pneumococcal vaccination reduces morbidity and mortality among older adults, yet coverage remains suboptimal in China. This study aimed to assess the effectiveness of a pay-it-forward intervention (covering two-thirds of the pneumococcal vaccination cost and offering the option to donate) in increasing pneumococcal vaccination among older adults (aged 60 years or older) in China, compared to standard-of-care self-paid vaccination.

Methods

We used block randomization (block size = 4) to assign participants to a pay-it-forward arm and a standard-of-care arm in a 1:1 ratio. The primary outcome was pneumococcal vaccination. Secondary outcomes included influenza vaccine uptake, vaccine confidence, successful vaccine referral, and cost-effectiveness. Logistic regression analysis was used to compare PPSV-23 and influenza vaccination coverage and vaccine confidence between the two groups. The cost-effectiveness of the interventions was assessed using a micro-costing approach from the healthcare provider’s perspective.

Results

From January to September 2024, 221 older adults were randomized (110 in the pay-it-forward group and 111 in the standard-of-care group). Pneumococcal and influenza vaccine uptake were significantly higher in the pay-it-forward arm (70.9% and 30.0%) than in the standard-of-care arm (13.5% and 17.1%), with adjusted odds ratios of 17.20 (95% CI, 8.39–37.60) and 2.29 (95% CI, 1.17–4.65). The pay-it-forward group also exhibited greater confidence in the safety (4.29, 95% CI, 1.78–11.50), importance (5.15, 95% CI, 2.05–14.60), and effectiveness (7.14, 95% CI, 2.36–27.50) of the vaccine than that in the standard-of-care group. The pay-it-forward group had a higher successful vaccine referral rate (15.5% vs. 10.8%) and had a lower economic cost per person vaccinated (US $95.67 vs. US $278.56) compared with the standard-of-care arm.

Conclusions

Our findings demonstrate that the pay-it-forward intervention significantly enhances pneumococcal and influenza vaccination coverage and improves vaccine confidence among the older adults. This study highlights the potential of the pay-it-forward intervention as an effective means to boost health service utilization.

Trial registration

2024–01-03, Chinese Clinical Trial Registry, ChiCTR2400079410.