Background <p>The Government of India recognizes the utilization of uniform information, communication, and technology (ICTs) applications which can improve understanding of the nation’s expanding health demands and rising non-communicable disease (NCD) burden. One such intervention is the development of the “National NCD Portal” was to aid healthcare providers in Population-Based Screening (PBS) initiative for common NCDs (diabetes, hypertension, cancers of the oral cavity, breast, and cervix) above 30 years of age. When such digital tools are introduced in healthcare, it is critical to understand users’ perspectives and experiences to further facilitate the increased integration of uniform ICTs into healthcare.</p> Materials and methods <p>The study exhibits a qualitative exploratory design that involves a thematic analysis of 19 in-depth interviews of users (5 Accredited Social Health Activists, 4 Auxiliary Nurse Midwives, 5 Community Health Officers, and 5 Medical Officers) from 5 different taluks of the district selected by purposive sampling.</p> Results <p>The users highly appreciated the user-friendly aspects of the portal, noting its positive impact on non-communicable disease management through enhanced accessibility of patient data to deliver better patient care. The key barriers were heavy workload, digital incompetence, and lack of accountability. The suggestions for the optimal utilization were the recruitment of a dedicated data entry operator and better accountability in addressing users’ needs.</p> Conclusion <p>The National NCD portal has shown a change in enhancing the management of NCDs through better data management and accessibility. Addressing technical reliability, enhancing support systems, and ensuring adequate staffing are essential steps to optimize the portal’s functionality. The study results recommend future evaluations in various settings to understand the long-term impact of the portal or any digital health interventions.</p>