Background <p>Despite advances in treatment and the well-established benefits of cardiac rehabilitation in Portugal, patient engagement in recovery after myocardial infarction remains limited. One contributing factor is the insufficient integration of person-centred care (PCC), which emphasises collaborative partnerships between patients and healthcare professionals to support recovery. PCC practices have been shown to improve self-efficacy in managing recovery from acute cardiac events. This study aimed to adapt a Swedish evidence-based PCC intervention to the Portuguese healthcare context, with the goal of enhancing patients’ self-efficacy following myocardial infarction.</p> Methods <p>The Portuguese person-centred care intervention to enhance self-efficacy in patients following a myocardial infarction (P2MIR) was adapted to the Portuguese healthcare context based on the Medical Research Council framework further enhanced by best practices for adapting interventions. A two-phase exploratory and qualitative study was conducted in co-design with several stakeholders, including researchers, patients who experienced a myocardial infarction, and healthcare professionals from a cardiology department. Implementation outcomes and key adaptations were assessed through four semi-structured focus group discussions with patients (<i>n</i> = 6) and healthcare professionals (<i>n</i> = 11). Data were analysed using a deductive content analysis approach.</p> Results <p>In Phase I, the intervention was systematically adapted to the Portuguese healthcare context, resulting in P2MIR 1.0. Phase II findings showed that participants perceived the PCC intervention to be acceptable and seemed appropriate, and feasible, with promising potential to integrate care across hospital, outpatient and primary care settings. Patients reported that PCC had the potential to lead to better care experiences, increased involvement in their recovery, and fewer unplanned visits, while professionals noted potential benefits for job satisfaction and clinical support. These insights guided the refinement of the intervention, leading to a final version, P2MIR 2.0.</p> Conclusions <p>The P2MIR 2.0 retain components from the original intervention with additional two co-designed components to further strengthen the possibility to create a partnership between healthcare professionals and myocardial infarction patients after hospital discharge, thereby enhancing self-efficacy in recovery. Targeted training in PCC for health care professionals, along with culturally adapted tools, will support integration and future scaling.</p>