Background <p>In Ghana, stroke prevalence and mortality are rising, placing substantial demands on informal caregivers, who provide essential support for patients’ daily needs. This study aimed to determine the burden of care among informal caregivers of stroke survivors and identify sociodemographic factors influencing caregiving experiences at Tamale Teaching Hospital.</p> Methods <p>A cross-sectional study design was conducted to assess the burden of care among 244 informal caregivers of stroke survivors at Tamale Teaching Hospital, Ghana. Participants were selected using simple random sampling, and data were collected between December 2024 to March 2025 using a structured 16-item Zarit Burden Interview questionnaire to measure physical, social, psychological, and financial dimensions of caregiving. Descriptive statistics summarised caregivers’ characteristics and support activities, while multivariate logistic regression identified sociodemographic predictors of caregiver burden.</p> Results <p>The study revealed that 61.1% of caregivers experienced variably levels of burden, with 26.6% reporting mild, 27.0% moderate, and 7.5% severe burden. Most caregivers assisted with medications (88.5%) and feeding (65.6%), with bathing being the least frequently provided. Age, education, employment status, and relationship to the stroke survivor were significant predictors of burden; caregivers aged 30–49 years, spouses, and siblings had higher odds of experiencing burden, whereas higher educational attainment and part-time employment were protective.</p> Conclusions <p>The findings highlight the critical role of informal caregivers and the multidimensional challenges they face. Interventions such as caregiver education, psychosocial support, and financial assistance are recommended to alleviate burden, improve caregiver well-being, and enhance the quality of care for stroke survivors in Ghana.</p>