Objective <p>This systematic review and meta-analysis evaluates the association between mobile nursing information systems (MNIS) and patient satisfaction with nursing care across diverse clinical settings.</p> Methods <p>In this systematic review and meta-analysis restricted to non-randomised quasi-experimental studies, we systematically searched eight electronic databases for literature published between January 2010 and October 2025 to identify eligible non-randomised controlled studies comparing MNIS with conventional nursing care. Randomised controlled trials were excluded to maintain methodological homogeneity for real-world implementation evidence. The primary outcome was patient-reported satisfaction with nursing care. A random-effects meta-analysis was performed using risk ratios (RRs) with 95% confidence intervals (CIs).</p> Results <p>Six studies involving 4,617 patients were included in the final synthesis. Pooled results indicated that MNIS were associated with a modest elevation in patient satisfaction with nursing care (RR: 1.13, 95%CI: 1.07–1.20, <i>P</i> &lt; 0.001), with substantial unexplained statistical heterogeneity across studies (<i>I²</i>=77.0%). Exploratory subgroup analyses detected positive correlational trends across outpatient infusion settings, inpatient wards and operating rooms. Sensitivity analyses confirmed the stability of the pooled correlational results.</p> Conclusions <p>Current low-certainty evidence suggests that MNIS are associated with slightly higher patient satisfaction with nursing care across multiple clinical scenarios. Given the non-randomised study design, high unexplained heterogeneity and limited evidence quality, causal relationships cannot be established. Further rigorous research using standardised outcome measures is needed to strengthen the evidence base.</p> Clinical trial number <p>not applicable.</p>