Introduction <p>Recently, new methods such as game-based learning, mobile learning, and telesimulation have been used in lessons. In this study, we aimed to evaluate the effects of game-based learning and telesimulation methods on the knowledge, skills, motivation, and self-efficacy levels of nursing students in postpartum hemorrhage management.</p> Methods <p>This randomized-controlled study comprised 177 nursing students who had attended an obstetrics and gynecology nursing course at a nursing department in Ankara, Türkiye. Participants were classified according to their grade point average and randomly assigned to four groups of equal size.</p> Results <p>After training, the knowledge, skill, motivation, and self-efficacy scores in postpartum bleeding management were higher in the groups where telesimulation (Group II), Game-based learning (Group III), and both methods were used together (Group IV) compared with the control group (Group I, <i>p</i> &lt; 0.001). Group IV scores were significantly higher than the other two experimental groups on knowledge (85.5 ± 9.3), skill (19.2 ± 6.3), motivation (141.2 ± 18.7), and self-efficacy (84.5 ± 7.9) scales (<i>p</i> &lt; 0.001).</p> Conclusion <p>Telesimulation and Game-based learning methods were more effective than virtual lecture for teaching postpartum hemorrhage management skills. However, during virtual lessons, combining telesimulation and Kahoot was more effective than all other methods.</p> Trial registration <p>ClinicalTrials.gov ID, NCT05323903, Retrospectively registered. Registered on April 5, 2022.</p>