Objective <p>The present study aims to examine the relationship between caregiver burden, compassion, and spiritual well-being in caregivers for bedridden patients.</p> Method <p>A descriptive and cross-sectional study. Data were collected from 130 caregivers for bedridden patients receiving home care and healthcare services in Mus Province. The Compassion Scale, Burden Interview Scale, and Spiritual Well-Being Scale have been used.</p> Result <p>The mean scores for each of the variables were as follows: mean score for caregiver burden was 42.67 ± 13.48, mean score for compassion was 82.38 ± 13.77, and mean score for spiritual well-being was 3.70 ± 0.58. The scores for caregiver burden were significantly correlated with scores for both compassion and spiritual well-being (<i>p</i> &lt; 0.001 for both). Additionally, the scores for compassion were also significantly correlated with scores for spiritual well-being (<i>p</i> &lt; 0.001).</p> Conclusion <p>The scores of the participants on the Burden Interview Scale, Compassion Scale, and Spiritual Well-Being Scale were found to be significantly higher than average.</p> Clinical trial number <p>Clinical trial number is not applicable.</p>